Paroxetine 20 mg versus paroxetine 40 mg (acute phase)

DescriptionStatementStatements and Statistics
the severity of PTSD symptoms as measured by clinician measure CAPSs3There is evidence suggesting there is unlikely to be a clinically important difference between paroxetine 20mg and paroxetine 40mg on reducing the severity of PTSD symptoms as measured by clinician measure CAPS (k = 1; n = 365; SMD = −0.06; 95% CI, −0.27 to 0.14). I
the severity of PTSD symptoms as measured by self-report DTSs3There is evidence suggesting there is unlikely to be a clinically important difference between paroxetine 20mg and paroxetine 40mg on reducing the severity of PTSD symptoms as measured by self-report DTS (k = 1; n = 365; SMD = −0.08; 95% CI, −0.29 to 0.12). I
depression symptoms as measured by Montgomery- Asberg Depression Rating Scales3There is evidence suggesting there is unlikely to be a clinically important difference between paroxetine 20mg and paroxetine 40mg on reducing depression symptoms as measured by Montgomery-Asberg Depression Rating Scale (k = 1; n = 365; SMD = −0.08; 95% CI, −0.29 to 0.12). I
Quality of lifes3There is evidence suggesting there is unlikely to be a clinically important difference between paroxetine 20mg and paroxetine 40mg on increasing quality of life (k = 1; n = 365; SMD = −0.08; 95% CI, −0.28 to 0.13). I
the likelihood of leaving treatment early for any reasons3There is evidence suggesting there is unlikely to be a clinically important difference between paroxetine 20mg and paroxetine 40mg on reducing the likelihood of leaving treatment early for any reason (k = 1; n = 375; RR = 0.89; 95% CI, 0.68 to 1.15). I

From: Appendix 16, Evidence statements

Cover of Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder: The Management of PTSD in Adults and Children in Primary and Secondary Care.
NICE Clinical Guidelines, No. 26.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): Gaskell; 2005.
Copyright © 2005, The Royal College of Psychiatrists & The British Psychological Society.

All rights reserved. No part of this book may be reprinted or reproduced or utilised in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers. Enquiries in this regard should be directed to the Royal College of Psychiatrists.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.