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National Collaborating Centre for Mental Health (UK). Obsessive-Compulsive Disorder: Core Interventions in the Treatment of Obsessive-Compulsive Disorder and Body Dysmorphic Disorder. Leicester (UK): British Psychological Society; 2006. (NICE Clinical Guidelines, No. 31.)

Appendix 5Clinical questions

APsychological intervention

1.For people with OCD, does BT, when compared with waitlist control/relaxation/anxiety management, behavioural stress management/another active psychological intervention produce benefits/harms on the specified outcomes?
2.For people with OCD, does CT, when compared with waitlist control/relaxation/anxiety management, behavioural stress management/another active psychological intervention produce benefits/harms on the specified outcomes?
3.For people with OCD, does CBT, when compared with waitlist control/relaxation/anxiety management, behavioural stress management/another active psychological intervention produce benefits/harms on the specified outcomes?
4.For people with OCD, does rational-emotive therapy (RET), when compared with waitlist control/relaxation/anxiety management, behavioural stress management/another active psychological intervention produce benefits/harms on the specified outcomes?
5.For people with OCD, does psychoanalysis, psychoanalytic psychotherapy, psychodynamic psychotherapy or supportive psychotherapy, when compared with waitlist control/relaxation/anxiety management – behavioural stress management/another active psychological intervention produce benefits/harms on the specified outcomes?
6.For people with OCD, does mind body therapy (MBT), when compared with waitlist control/relaxation/anxiety management, behavioural stress management/another active psychological intervention produce benefits/harms on the specified outcomes?
7.For people with OCD, does family therapy, when compared with waitlist control/relaxation/anxiety management, behavioural stress management/another active psychological intervention produce benefits/harms on the specified outcomes?
8.For people with OCD, does any other psychological intervention (yoga), when compared with waitlist control/relaxation/anxiety management, behavioural stress management/another active psychological intervention produce benefits/harms on the specified outcomes?

BPharmacological interventions

1.For people with OCD (BDD), do tricyclic antidepressants (amitriptyline, desipramine, imipramine, nortriptyline, excluding clomipramine), when compared with placebo/comparator drug, produce benefits/harms on the specified outcomes?
2.For people with OCD (BDD), does clomipramine, when compared with placebo/comparator drug, produce benefits/harms on the specified outcomes?
3.For people with OCD (BDD), do SSRIs (citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline), when compared with placebo/comparator drug, produce benefits/harms on the specified outcomes?
4.For people with OCD (BDD), do atypical SRIs, when compared with placebo/comparator drug, produce benefits/harms on the specified outcomes?
5.For people with OCD (BDD) do SNRIs (venlafaxine), when compared with placebo/comparator drug, produce benefits/harms on the specified outcomes?
6.For people with OCD, do MAOIs (phenelzine), when compared with placebo/comparator drug, produce benefits/harms on the specified outcomes?
7.For people with OCD (BDD), do anxiolytics (buspirone, clonazepam), when compared with placebo/comparator drug, produce benefits/harms on the specified outcomes?
8.For people with OCD (BDD), do antipsychotics, when compared with placebo/comparator drug, produce benefits/harms on the specified outcomes?
9.For people with OCD (BDD), does any other pharmacological intervention (inositol, oxytocin), when compared with placebo/comparator drug, produce benefits/harms on the specified outcomes?
10.For people with OCD, do augmentation strategies (buspirone, clomipramine, desipramine, haloperidol, inositol, lithium, nortriptyline, olanzapine, pindolol, quetiapine, risperidone, triiodothyronine), when compared with placebo/comparator drug, produce benefits/harms on the specified outcomes?
11.For people with OCD, does any drug treatment, when compared with any psychological intervention, produce benefits/harms on the specified outcomes?
12.For people with OCD, does the combination of a drug treatment and a psychological intervention, when compared with a drug treatment alone/psychological intervention alone, produce benefits/harms on the specified outcomes?

COther biological interventions

1.For people with OCD, does neurosurgery (stereotactic anterior capsulotomy/cingulotomy), when compared with placebo/waitlist control/drug treatment/any psychological intervention, produce benefits/harms on the specified outcomes?
2.For people with OCD, does deep brain stimulation (electrical capsular stimulation), when compared with placebo/waitlist control/drug treatment/any psychological intervention, produce benefits/harms on the specified outcomes?
3.For people with OCD, does transcranial magnetic stimulation, when compared with placebo/waitlist control/drug treatment/any psychological intervention, produce benefits/harms on the specified outcomes?
4.For people with OCD, does ECT, when compared with placebo/waitlist control/drug treatment/any psychological intervention, produce benefits/harms on the specified outcomes?
5.For people with OCD, do other interventions, when compared with placebo/waitlist control/drug treatment/any psychological intervention, produce benefits/harms on the specified outcomes?
Copyright © 2006, The British Psychological Society & The Royal College of Psychiatrists.

All rights reserved. No part of this book may be reprinted or reproduced or utilised in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers. Enquiries in this regard should be directed to the British Psychological Society.

Cover of Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder: Core Interventions in the Treatment of Obsessive-Compulsive Disorder and Body Dysmorphic Disorder.
NICE Clinical Guidelines, No. 31.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2006.

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