Magiati et al., 2007

Study DescriptionInterventionInclusion/Exclusion
Criteria/Population
Baseline MeasuresOutcomes
Author:
Magiati et al., 2007
Country:
UK
Practice setting:
Academic
Intervention setting:
Community
Enrollment period:
July 1998 to July 2002
Funding:
Local educational authorities
Author industry relationship disclosures:
None
Design:
Prospective cohort
Intervention:
Early Intensive Behavioral Intervention: children received 1:1 home teaching using discrete trial techniques and Verbal Behavior; 27 families attended an initial workshop of 1–3 days
Nursery: eclectic intervention, emphasizing structure, visual cues, individualized teaching, and contact with families (most commonly reported TEACCH, PECS, Makatan, and SPELL) Duration of treatment, months ± SD (range):
G1: 25.5 ± 1.04 (23–27)
G2: 26.0 ± 1.5 (23–27)
Total hours of intervention, mean ± SD:
G1: 3,415 ± 444
G2: 2,266 ± 533
Hours of intervention per week, mean ± SD (range):
First week:
G1: 32.4 ± 6.4 (18–40)
G2: 25.6 ± 6.4 (15–30)
G1/G2: P < 0.001
Last week:
G1: 33.2 ± 3.5 (26–40)
G2: 27.4 ± 4.2 (19–30)
G1/G2: P < 0.001
Assessments:
BSID, WPPSI, MPS, VABS, BPVS-II, Word Picture Vocabulary Test- Revised, Symbolic Play Test-II, Test of Pretend Play, administered at home or school by investigators at baseline and follow-up
Groups:
G1: EIBI
G2: nursery
Inclusion criteria:
  • Age 22–54 months
  • Independent professional diagnosis of autism/ASD confirmed by ADI-R
  • No major medical diagnoses
  • English main language at home
  • Living within 3 hours of London
  • Enrolled in either EIBI home-based program or specialist autism- specific school-based nursery provision for a minimum of 15 hours per week
  • Receiving no other intensive treatment
Exclusion criteria:
  • See inclusion criteria
Age, months ± SD:
G1: 38 ± 7.2
G2: 42.5 ± 7.8
Mental age, mean ± SD (range):
See baseline measures
Gender, n (%):
Male:
G1: 27 (96.4)
G2: 12 (75)
Female:
G1: 1 (3.6)
G2: 4 (25)
Race/ethnicity, n (%):
White:
G1: 21 (47)
G2: 11 (69)
Mixed:
G1: 4 (9)
G2: 0
Asian/Asian British:
G1: 2 (45)
G2: 2 (13)
Black/Black British:
G1: 1 (2)
G2: 3 (19)
Overall measures:
VABS composite, standard score, mean ± SD (range):
G1: 59.6 ± 6.2 (50–72) (n=26)
G2: 55.4 ± 5.4 (47–64) (n=14)
G1/G2: P = 0.04
ADI-R total algorithm score, mean ± SD (range):
G1: 36.4 ± 6.7 (18–46) (n=26)
G2: 40 ± 6.9 (18–46) (n=15)
G1/G2: P = NS
Educational/cognitive/academic attainment:
Mental age, months ± SD (range):
G1: 31.4 ± 11.1 (5–55 )
G2: 29.1 ± 13.1 (9–48)
G1/G2: P = NS IQ, mean ± SD (range):
G1: 83 ± 27.9 (16–138)
G2: 65.2 ± 26.9 (27–112 )
G1/G2: P = 0.04
Symbolic play test score, developmental age, months ± SD (range):
G1: 18.8 ± 8 (12–36) (n=27)
G2: 19.2 ± 8.6 (12–34)
G1/G2: P = NS
BPVS score, mean ± SD (range):
G1: 4.9 ± 9.1 (0–32)
G2: 2.9 ± 7.7 (0–27)
G1/G2: P = NS
Overall measures:
VABS composite, age equivalent, months ± SD (range):
G1: 32.6 ± 10.2 (19–58)
G2: 26.1 ± 12.4 (11–48)
G1/G2: P = NS
VABS composite, standard score, mean ± SD (range):
G1: 57.5 ± 10.1 (41–79)
G2: 48.6 ± 10.7 (35–72)
G1/G2: P = NS
ADI-R total algorithm score, mean ± SD (range):
G1: 30.7 ± 8.8 (13–40) (n=26)
G2: 34.9 ± 9.9 (11–48)
G1/G2: P = NS
Educational/cognitive/academic attainment:
Mental age, months ± SD (range):
G1: 49.2 ± 9.8 (29–70)
G2: 44.7 ± 14.1 (17–67) (n=15)
G1/G2: P = NS
IQ, mean ± SD (range):
G1: 78.4 ± 17.6 (43–129)
G2: 65.3 ± 18 (30–94) (n=15)
G1/G2: P = NS
Provider:
EIBI provider, n (%):
Supervisor and consultant: 14 (50)
Supervisor: 7 (25)
Consultant: 3 (11)
Senior therapist: 2 (7)
One-two parents trained as a therapist: 23 (82)
Nursery provider, n (%):
Teachers: 16 (100)
Measure of treatment fidelity reported:
No
Co-interventions held stable during treatment:
NR
Concomitant therapies, n:
Special Dietary:
G1: 21
G2: 6
G1/G2: P = 0.01
Other biological interventions:
G1: 17
G2: 3
G1/G2: P = 0.01
Extra-curricular educational interventions:
G1: 2
G2: 7
G1/G2: P < 0.01
Other alternative treatments:
G1: 8
G2: 2
G1/G2: P = 0.18
N at enrollment:
G1: 28
G2: 16
N at follow-up:
G1: 28
G2: 16
SES:
Parental education, n:
Higher (degree or above):
G1: 18
G2: 7
Lower (A-levels or below):
G1: 5
G2: 8
No information:
G1: 5
G2: 1
Family SEC, n:
Higher (categories 1–3):
G1: 23
G2: 9
Lower (categories 4–9):
G1: 4
G2: 6
No information:
G1: 1
G2: 1
Diagnostic approach:
In Study Diagnostic tool/method:
ADI-R
Diagnostic category, n (%):
Autism:
G1: 19 (43)
G2: 13 (81)
ASD:
G1: 9 (20)
G2: 3 (19)
Other characteristics:
NR
Communication/language:
EOWPVT-R score, mean ± SD (range):
G1: 2.2 ± 7.8 (0–39)
G2: 1.7 ± 3.7 (0–12)
G1/G2: P = NS
VABS communication, age equivalent, months ± SD (range):
G1: 14.4 ± 5.2 (8–28) (n=26)
G2: 13.1 ± 4.5 (8–26) (n=14)
G1/G2: P = NS
VABS communication, standard score, mean ± SD (range):
G1: 60 ± 7.4 (50–78) (n=26)
G2: 55.8 ± 6.8 (47–74) (n=14)
G1/G2: P = NS
Adaptive behavior:
VABS daily living, age equivalent, months ± SD (range):
G1: 19 ± 6.1 (11–39) (n=26)
G2: 20 ± 3.9 (15–27) (n=14)
G1/G2: P = NS
VABS daily living, standard score, mean ± SD (range):
G1: 63 ± 7.4 (55–89) (n=26)
G2: 61.4 ± 4.9 (52–69) (n=14)
G1/G2: P = NS
Social skills:
VABS socialization, age equivalent, months ± SD (range):
G1: 13 ± 4.4 (6–24) (n=26)
G2: 11.1 ± 3.4 (6–20) (n=14)
G1/G2: P = NS
Symbolic play test score, developmental age, months ± SD (range):
G1: 29.2 ± 12.7 (12–65)
G2: 28.8 ± 13 (12–61) (n=15)
G1/G2: P = NS
BPVS score, mean ± SD (range):
G1: 20.8 ± 20.8 (0–68) (n=27)
G2: 13.2 ± 17.8 (0–52) (n=15)
G1/G2: P = NS
Communication/language:
EOWPVT-R score, mean ± SD (range):
G1: 13 ± 17.3 (0–59) (n=27)
G2: 10.2 ± 13.7 (0–38) (n=15)
G1/G2: P = NS
VABS communication, age equivalent, months ± SD (range):
G1: 29.6 ± 17.2 (12–70)
G2: 23.6 ± 16.8 (11–67)
G1/G2: P = NS
VABS communication, standard score, mean ± SD (range):
G1: 61.2 ± 17.6 (41–106)
G2: 51.6 ± 14.8 (37–87)
G1/G2: P = NS
VABS socialization, standard score, mean ± SD (range):
G1: 60.3 ± 6 (51–76) (n=26)
G2: 56.6 ± 4.8 (52–67) (n=14)
G1/G2: P = 0.05
VABS composite, age equivalent, months ± SD (range):
G1: 18.6 ± 5.4 (12–32) (n=26)
G2: 17.3 ± 3.9 (12–26) (n=14)
G1/G2: P = NS
Adaptive behavior:
VABS daily living, age equivalent, months ± SD (range):
G1: 32.4 ± 8.2 (20–55)
G2: 29.4 ± 9.7 (17–49)
G1/G2: P = NS
VABS daily living, standard score, mean (SD); range:
G1: 58.6 ± 8.4 (38–78)
G2: 49.6 ± 12.4 (28–73)
G1/G2: P = 0.06
Social skills:
VABS socialization, age equivalent, months ± SD (range):
G1: 25.1 ± 11.8 (12–61)
G2: 20.2 ± 14 (7–53)
G1/G2: P = NS
VABS socialization, standard score, mean ± SD (range):
G1: 61.8 ± 10.4 (41–90)
G2: 56.7 ± 10.3 (47–82)
G1/G2: P = NS
Harms:
NR
Modifiers:
Progress after 2 years was best predicted by baseline IQ (P < 0.001) and baseline PBVS score (P < 0.01); VABS and ADI-R total scores also contributed to the model (P < 0.05)

From: Appendix C, Evidence Tables

Cover of Therapies for Children With Autism Spectrum Disorders
Therapies for Children With Autism Spectrum Disorders.
Comparative Effectiveness Reviews, No. 26.
Warren Z, Veenstra-VanderWeele J, Stone W, et al.

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