Salt et al., 2002

Study DescriptionInterventionInclusion/Exclusion
Criteria/Population
Baseline MeasuresOutcomes
Author:
Salt et al., 2002
Country:
Scotland UK
Practice setting:
Specialty treatment center
Intervention setting:
Clinic
Enrollment period:
NR
Funding: NHS
Author industry relationship disclosures:
NR
Design:
Non-RCT
Intervention:
Individualized treatment focusing on social, communicative, play, and adaptive behaviors; 8 hours every two weeks for 11 months
Parent training component focusing on behavior management and teaching new skills
Assessments:
All occurred pre- and post-treatment Parent reports: Standardized stress measure and satisfaction questionnaire Clinician conducted: Bayley Scales of Infant Development – 2nd ed; British Picture Vocabulary Scale; VABS; PVCS; MCDI; Symbolic Play Test – 2nd ed; ESCS; PSI – 3rd ed.
Groups:
G1: (SCA) intervention
G2: Control/other intervention

Duration (mean ± SD):
Non-SCA intervention (hrs/fortnight):
Nursery:
G1: 27.58 ± 13.32
G2: 38.7 ± 19.45
Other 1:1 therapy:
G1: 2.79 ± 9.06
G2: 2.2 ± 2.28

Provider:
  • Therapists including nursery nurses, teachers, OT, PT, SLT
  • Parents
Treatment manual followed:
NR
Defined protocol followed:
NR
Inclusion criteria:
  • Preschool age range
  • Accessible geographical location
  • Diagnosis of Autism
  • Children not excluded on the basis of developmental delay
Exclusion criteria:
  • See inclusion criteria
Age, months ± SD:
G1: 42.36 ± 7.16
G2: 37.67 ± 3.08
Mental age, months ± SD:
G1: 17 ± 5.51
G2: 20.83 ± 2.32
Gender, n (%):
Male:
G1: 11 (92)
G2: 3 (60)
Female:
G1: 1 (8)
G2: 2 (40)
Race/ethnicity, n (%):
White: 16 (94)
Middle eastern: 1 (6)
SES:
NR
Diagnostic approach:
Referral
Diagnostic tool/method:
ICD-10 (WHO, 1993) diagnosis of childhood autism
Diagnostic category, n (%):
Autism: 17 (100)
Other characteristics, IQ (MA/CA) × 100, mean ± SD:
G1: 39.43 ± 13.47
G2: 55.67 ± 6.59
Social skills:
VABS score, mean ± SD:
Socialization:
G1: 51.83 ± 1.9
G2: 55.0 ± 3.39
Symbolic play test score, mean ± SD:
G1: 2.27 ± 3.5
G2: 12.8 ± 4.82
Communication/language:
VABS Communication:
G1: 51.17 ± 2.79
G2: 54.8 ± 3.11
MCDI, mean ± SD:
Words understood:
G1: 62.55 ± 44.68
G2: 55.6 ± 42.75
Words produced:
G1: 4.73 ± 7.46
G2: 11.6 ± 15.08
PVCS imitation score, mean ± SD:
G1: 1.92 ± 2.15
G2: 1.6 ± 0.55
ESCS score, mean ± SD:
Joint attention:
G1: 5.44 ± 3.17
G2: 6.0 ± 3.39
Requesting behavior:
G1: 3.67 ± 2.12
G2: 6.6 ± 5.59
Social interaction:
G1: 3.33 ± 2.0
G2: 4.2 ± 2.86
Adaptive behavior:
VABS Composite score:
G1: 49.5 ± 3.75
G2: 54.6 ± 4.83
VABS Daily living skills:
G1: 53.08 ± 6.26
G2: 59.0 ± 3.46
Motor skills:
VABS Motor skills:
G1: 55.92 ± 11.37
G2: 69.8 ± 10.89
Social skills:
VABS socialization score, mean ± SD:
G1: 54.08 ± 2.91
G2: 52.8 ± 2.95
P < 0.05
ESCS symbolic play test score, mean ± SD:
G1: 6.91 ± 5.94
G2: 19.6 ± 3.78
P = NS
ESCS joint attention score, mean ± SD:
G1: 9.11 ± 5.58
G2: 4.6 ± 2.97
P < 0.05
ESCS request behavior score, mean ± SD:
G1: 10.33 ± 6.96
G2: 6.2 ± 2.77
P = NS (P < 0.06)
ESCS social interaction score, mean ± SD:
G1: 5.22 ± 2.73
G2: 3.2 ± 0.84
P < 0.05
Communication/language:
VABS communication score, mean ± SD:
G1: 46.17 ± 15.07
G2: 50.6 ± 1.82
P = NS
MCDI, words understood, mean ± SD:
G1: 91.18 ± 68.51
G2: 79.8 ± 50.16
P = NS
MCDI, words produced, mean ± SD:
G1: 17.82 ± 40.94
G2: 31.20 ± 22.61
P = NS
Measure of treatment fidelity reported:
Yes
Measure of reliability reported:
Yes
Co-interventions held stable during treatment:
NR
Concomitant therapies:
NR
N at enrollment:
G1: 14
G2: 6
N at follow-up:
G1: 12
G2: 5
PVCS imitation score, mean ± SD:
G1: 7.67 ± 5.35
G2: 3.8 ± 0.84
P < 0.05
Adaptive behavior:
VABS composite score, mean ± SD:
G1: 49.33 ± 7.09
G2: 48.6 ± 2.3
P < 0.05
VABS daily living skills score, mean ± SD:
G1: 53.67 ± 9.93
G2: 50.8 ± 2.95
P < 0.05
Motor skills:
VABS motor skill score, mean ± SD:
G1: 55.92 ± 15.06
G2: 55.66 ± 5.32
P < 0.05
Harms:
NR
Modifiers:
NR

From: Appendix C, Evidence Tables

Cover of Therapies for Children With Autism Spectrum Disorders
Therapies for Children With Autism Spectrum Disorders.
Comparative Effectiveness Reviews, No. 26.
Warren Z, Veenstra-VanderWeele J, Stone W, et al.

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