Table 16Meta-analyses 1 and 2, for sensitivity and specificity of variant allelic determination to diagnose TPMT enzymatic activity

Meta-analysis 1
Normal/high activityIntermediate/low/absent activitySensitivity 1Specificity 1
Homozygotes and/or heterozygotesA1B1B1/(B1+D1)C1/(C1+A1)
Noncarrier (or Wild types)C1D1
Meta-analysis 2
Normal/high/intermediate activityLow/absent activitySensitivity 2Specificity 2
HomozygotesA2B2B2/(B2+D2)C2/(C2+A2)
Noncarrier (or Wild types) and/or heterozygotesC2D2

From: 3, Results

Cover of Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-Based Drugs
Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-Based Drugs.
Evidence Reports/Technology Assessments, No. 196.
Booth RA, Ansari MT, Tricco AC, et al.

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