Figure 11 depicts a meta-analysis of sensitivity and specificity of genotyping TPMT *3A, *3B and *3C, to diagnose TPMT activity. The figure is divided into three columns with the heading reading left to right: Study, Sensitivity† Specificity‡, and Sensitivity and Specificity (95 percent confidence interval). From left to right, the results are: Ansari, 2008-- 17/23 and 168/169--73.9 (52.8, 87.8); Langley, 2002--6/8 and 40/44--66.7 (33.3, 88.9), 90.9 (78.2, 96.5); Pooled--71.8, (54.0, 84.6) and 97.3 (69.6, 99.8).

Figure 11Meta-analysis 1 of sensitivity and specificity of genotyping TPMT *3A, *3B and *3C, to diagnose TPMT activity

(Homozygotes or heterozygotes with intermediate or low to absent enzymatic activity) (all with intermediate or low enzymatic activity)

(Noncarriers or wild type genotype with normal/high enzymatic activity) (all with normal or high enzymatic activity)

From: 3, Results

Cover of Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-Based Drugs
Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-Based Drugs.
Evidence Reports/Technology Assessments, No. 196.
Booth RA, Ansari MT, Tricco AC, et al.

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