Table C-4KQ1c: Diagnostic sensitivity and specificity of TPMT determinations – risk of bias assessment of included studies, part 1

StudyRepresentative spectrum of patientsClear Description of selection criteriaActivity assay correctly measures enzyme activitiesWhole or random sample administered activity testTPMT activity test administered independent of genotype resultsIndependence of TPMT activity and genotyping testsGenotyping method description clear for replicationTPMT activity test method description clear for replication
Ansari, 200828YesClearYesUnclearUnclearYesUnclearClear
Ansari, 200229UnclearClearYesYesYesYesClearClear
Gardiner, 200830NoClearYesNoYesYesClearClear
Haglund, 200431NoPartially clearYesYesYesYesClearClear
Hindorf, 200632UnclearClearYesYesYesYesClearClear
Hindorf, 200433NoClearYesYesYesYesClearClear
Langley, 200234UnclearClearYesUnclearYesYesClearClear
Lindqvist, 200635UnclearClearYesYesYesYesClearClear
Marinaki, 200336UnclearUnclearYesYesYesYesClearClear
Okada, 200537UnclearUnclearYesUnclearUnclearYesUnclearClear
Schwab, 200238UnclearPartially clearYesYesYesYesClearClear
Snow, 199539UnclearUnclearYesYesYesYesUnclearClear
Stassen, 200940UnclearUnclearYesYesYesYesClearClear
Stocco, 200541UnclearClearYesUnclearUnclearYesClearClear
Stocco, 200442UnclearPartially clearYesUnclearUnclearYesClearClear
von Ahsen, 200543UnclearClearYesYesYesYesClearClear
Winter, 200744UnclearUnclearYesYesYesYesClearClear
Newman, 201045UnclearClearYesYesYesYesYesYes
Hindorf, 201046UnclearUnclearYesYesYesYesYesYes

Abbreviations: TPMT = thiopurine methyltransferase.

From: Appendix C, Evidence Tables

Cover of Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-Based Drugs
Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-Based Drugs.
Evidence Reports/Technology Assessments, No. 196.
Booth RA, Ansari MT, Tricco AC, et al.

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