International Cooperative Study on Cardio-vascular Epidemiology

Derivation of prognostic modelKeys et al. 197271
Location & dateUS railroads employees, 13 European cohorts
Population characteristicsN=11,132
Age 40–59
100% male
Inclusion, co-morbidityCHD free
Risk factorsAge
Systolic blood pressure
Cholesterol
Smoking
BMI
OutcomeCHD
Prediction period5 years
Statistical methodsMultiple logistic equation
Practical
Authors notesSeparate risk equations for US and Europe
Modifications, tools or guidelinesKhosla 1977220 Simplified equation for use on pocket calculator
External validation
Convergent validation
Trials of health outcomes

From: Appendix 3, Prognostic models or risk scoring methods for use in targeting primary prevention of cardiovascular diseases (part completed)

Cover of A Systematic Review of Risk Scoring Methods and Clinical Decision Aids Used in the Primary Prevention of Coronary Heart Disease (Supplement)
A Systematic Review of Risk Scoring Methods and Clinical Decision Aids Used in the Primary Prevention of Coronary Heart Disease (Supplement) [Internet].
NICE Clinical Guidelines, No. 67S.
Beswick AD, Brindle P, Fahey T, et al.
Copyright © 2008, Royal College of General Practitioners.

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