Table APriority medication comparisons included for each of the key questions

Main interventionComparisons
Monotherapy as main interventionMetformin
  • Thiazolidinedione
  • Sulfonylurea
  • DPP-4 inhibitor
  • Meglitinides
  • GLP-1 agonist
  • Combination of metformin plus thiazolidinedione
  • Combination of metformin plus sulfonylurea
  • Combination of metformin plus DPP-4 inhibitor
  • Combination of metformin plus meglitinides
  • Combination of metformin plus GLP-1 agonist
Thiazolidinedione
  • Different thiazolidinedione
  • Sulfonylurea
  • DPP-4 inhibitor
  • Meglitinides
  • GLP-1 agonist
Sulfonylurea
  • DPP-4 inhibitor
  • Meglitinides
  • GLP-1 agonist
DPP-4 inhibitor
  • Meglitinides
  • GLP-1 agonist
Combination therapy as main interventionCombination of metformin plus (a thiazolidinedione or a sulfonylurea or one of the meglitinides or a DPP-4 inhibitor or a GLP-1 agonist or a basal insulin or a premixed insulin)
  • Combination of metformin plus (a thiazolidinedione or a sulfonylurea or a meglitinides or DPP-4 inhibitor or GLP-1 agonist or a basal insulin or a premixed insulin)
Combination of metformin plus (a thiazolidinedione or a sulfonylurea or a meglitinides or DPP-4 inhibitor or GLP-1 agonist or a basal insulin or a premixed insulin)
  • Combination of a thiazolidinedione plus (a sulfonylurea or a meglitinides or DPP-4 inhibitor or GLP-1 agonist)

DPP-4 inhibitor = dipeptidyl peptidase-4 inhibitor; GLP-1 agonist = glucagon-like peptide-1 receptor agonist

From: Executive Summary

Cover of Oral Diabetes Medications for Adults With Type 2 Diabetes: An Update
Oral Diabetes Medications for Adults With Type 2 Diabetes: An Update [Internet].
Comparative Effectiveness Reviews, No. 27.
Bennett WL, Wilson LM, Bolen S, et al.

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