Evidence statements

Level of evidenceEvidence statement
Level 1+ to 1-A gold standard medication for rapid tranquillisation has not yet been established
Level 1+ to 1-There appear to be no conclusive benefits in terms of effectiveness of one antipsychotic over another; of antipsychotics over benzodiazepines; or of combination medications over single medication regimes for rapid tranquillisation.
Level 1+ to 1-The body of evidence suggests rapid tranquillisation as an intervention for the short-term management of disturbed/violent behaviour is both reasonably effective and reasonably safe. This evidence suggests that both benzodiazepines and antipsychotics appear to be effective and reasonably safe for use in rapid tranquillisation.
Level 4It is not possible to determine the safety or effectiveness of medications other than antipsychotics and benzodiazepines for rapid tranquillisation.

From: 7, Methods and findings

Cover of Violence
Violence: The Short-Term Management of Disturbed/Violent Behaviour in In-Patient Psychiatric Settings and Emergency Departments.
NICE Clinical Guidelines, No. 25.
National Collaborating Centre for Nursing and Supportive Care (UK).
Copyright © 2006, Royal College of Nursing.

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