Table A16-33Aripiprazole versus placebo for the treatment of non-cognitive symptoms of dementia (serious adverse events)

Systematic review: Schneider, L. S., Dagerman, K. S., and Insel, P. (2005). Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA, 294, 1934–1943. McDonagh, M., Peterson, K., Freeman, M., & Carson, S. (2005). Drug class review on atypical antipsychotic drugs. Final report. Oregon Evidence-based Practice Center.

Quality assessmentSummary of findings
No of patientsEffectQualityImportance
No of studiesDesignLimitationsConsistencyDirectnessOther considerationsaripiprazoleplaceboRelative (95% CI)Absolute (95% CI)
Death (Number of deaths during trial, Follow up: )
3Randomised trialsNo limitationsNo important inconsistencyNo uncertaintyNone21/603 (3.5%)6/348 (1.7%)RR 1.71 (0.70 to 2.19)10/1 000 (−10 to +30)⊕⊕⊕⊕
High
9
Death (patient-years exposure) (Deaths based on total drug & placebo exposures pooled by drug Follow up: 1 year (predicted))
3Randomised trialsNo limitationsNo important inconsistencyNo uncertaintyNone21/95 (22.1%)6/54 (11.1%)RR 1.99 (0.86 to 4.62)110/1 000 (−10 to +230)⊕⊕⊕⊕
High
9

From: APPENDIX 16, EVIDENCE PROFILE TABLES FOR QUANTITATIVE REVIEWS

Cover of Dementia
Dementia: A NICE-SCIE Guideline on Supporting People With Dementia and Their Carers in Health and Social Care.
NICE Clinical Guidelines, No. 42.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2007.
Copyright © 2007, The British Psychological Society & The Royal College of Psychiatrists.

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