Table 59Study characteristics of included placebo-controlled trials of anticonvulsants

CarbamazepineValproateLamotrigineTopiramate
No. trials (Total participants)1 RCT (20)3 RCTs (292)1 RCT (27)3 RCTs (129)
Study IDsDELAFUENTE1994
TRITT2003
N/% female20/70
  1. 30/100
  2. 16/unclear but around 50
  3. 246/31
27/100
  1. 56/100
  2. 31/100
  3. 44/0
Mean age32
  1. 27
  2. 39
  3. 40
29
  1. 25
  2. 26
  3. 29
Axis I/II disordersSpecifically excluded
  1. Bipolar II
  2. Specifically excluded
  3. Cluster B, intermittent explosive disorder or PTSD
Excluded most major axis I disorders(1) 73% depressive disorders; 52% anxiety; 13% obsessive-compulsive disorder (OCD); 63% somatoform disorders
(2)–(3) SMI excluded
TreatmentCarbamazepine mean serum levels achieved 6.44 μg to 7.07 μg(1)–(3) DivalproexLamotrigine
  1. Topiramate 200 mg
  2. 250 mg
  3. 250 mg
Additional interventionAtheoretical psychotherapy(1)–(2) None
(3) 17% used an antidepressant; small number used zolpidem for sleep problems
NoneNone
SettingInpatients, Belgium
  1. Symptomatic volunteers
  2. Mixed sample
  3. Outpatients, all US
Symptomatic volunteers; FinlandSymptomatic volunteers; Germany
Length of treatmentMean 4.5 weeks
  1. 6 months
  2. 10 weeks
  3. 12 weeks
8 weeks
  1. 12 weeks
  2. 8 weeks
  3. 8 weeks
Length of follow-upNoneNoneNoneNone
Notes(2) Very high dropout rate data not useable
(3) Allowed to continue antidepressants if taken them for ≥ 2 months at baseline and stable

From: 6, PHARMACOLOGICAL AND OTHER PHYSICAL TREATMENTS IN THE MANAGEMENT OF BORDERLINE PERSONALITY DISORDER

Cover of Borderline Personality Disorder
Borderline Personality Disorder: Treatment and Management.
NICE Clinical Guidelines, No. 78.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2009.
Copyright © 2009, The British Psychological Society & The Royal College of Psychiatrists.

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