Table 98Summary evidence table for studies reporting impulsivity outcomes

ComparisonPopulationEffect size
Quality of evidence
Number of studies, number of participants
Forest plot
Clinician-ratedSelf-rated
Antipsychotics
Antipsychotics versus placebo
Haloperidol versus placeboInpatients, some with comorbid depressive disorders or schizotypal personality disorderSMD = 0.07 (−0.3, 0.43)
Very low
(K = 2; n = 114)
Pharm 10.01
SMD = 0.18 (−0.34, 0.7)
Very low
(K = 1; n = 58)
Pharm 10.02
Ziprasidone versus placeboOutpatientsSMD = −0.06 (−0.57, 0.44)
Very low
(K = 1; n = 60)
Pharm 10.01
Antidepressants
Amitriptyline versus placeboMix of unstable borderline personality disorder and schizotypal personality disorder; moderate depression at baseline; inpatientsSMD = −0.12 (−0.64, 0.4)
Very low
(K = 1; n = 57)
Pharm 10.01
Phenelzine versus placeboMix of borderline personality disorder and schizotypal personality disorder with axis I disorders; moderate depression at baseline; inpatientsSMD = 0 (−0.5, 0.5)
Very low
(K = 1; n = 62)
Pharm 10.01
Phenelzine versus placebo (follow-up at 21 weeks)Mix of borderline personality disorder and schizotypal personality disorder with axis I disorders; moderate depression at baseline; inpatientsSMD = 0.26 (−0.24, 0.76)
Very low
(K = 1; n = 62)
Pharm 10.02

From: 6, PHARMACOLOGICAL AND OTHER PHYSICAL TREATMENTS IN THE MANAGEMENT OF BORDERLINE PERSONALITY DISORDER

Cover of Borderline Personality Disorder
Borderline Personality Disorder: Treatment and Management.
NICE Clinical Guidelines, No. 78.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2009.
Copyright © 2009, The British Psychological Society & The Royal College of Psychiatrists.

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