Long Term Lithium Combinations Evidence Profile

DescriptionStudy IdsQuality of included studiesConsistencyDirectnessOther factorsN treatment groupN controlEffect sizeLikelihood of clinically important effectOverall quality
Lithium + Imipramine vs Lithium
01 Relapse: Not remaining well (including non- completers)Prien 1984A
Quitkin 1981A
SIGN: 1+ Insufficient details on randomisationNo significant heterogeneityMost recent episode not clearSparse/imprecise data (−1)7482RR= 1.11 (0.83, 1.48)InconclusiveLow
02 Relapse: Mania - diagnostic criteria (including non- completers)Prien 1984A
Quitkin 1981A
SIGN: 1+ Insufficient details on randomisationNo significant heterogeneityMost recent episode not clearSparse/imprecise data (−1)7482RR= 1.47 (0.83, 2.61)InconclusiveLow
03 Relapse: Depression - diagnostic criteria (including non- completers)Prien 1984A
Quitkin 1981A
SIGN: 1+ Insufficient details on randomisationNoneMost recent episode not clearSparse/imprecise data (−1)7482RR= 0.74 (0.37, 1.45)InconclusiveLow
01 Leaving the study early for any reason (except relapse)Prien 1984A
Quitkin 1981A
SIGN: 1+ Insufficient details on randomisationNoneMost recent episode not clearSparse/imprecise data (−1)7482RR= 1.02 (0.68, 1.54)InconclusiveLow
02 Leaving the study early due to side effectsPrien 1984ASIGN: 1+ Insufficient details on randomisationNoneMost recent episode not clearSparse/imprecise data (−1)3744RR= 3.55 (0.15, 84.69)InconclusiveLow
Lithium + Imipramine vs Imipramine
01 Relapse: Not remaining well (including non- completers)Prien 1984ASIGN: 1+ Insufficient details on randomisationNoneMost recent episode not clearSparse/imprecise data (−1)3736RR= 0.74 (0.58, 0.94)Likely (favours lithium + imipramine)Moderate
02 Relapse: Mania - diagnostic criteria (including non- completers)Prien 1984ASIGN: 1+ Insufficient details on randomisationNoneMost recent episode not clearSparse/imprecise data (−1)3736RR= 0.51 (0.28, 0.95)Likely (favours lithium + imipramine)Moderate
03 Relapse: Depression - diagnostic criteria (including non- completers)Prien 1984ASIGN: 1+ Insufficient details on randomisationNoneMost recent episode not clearSparse/imprecise data (−1)3736RR= 0.78 (0.35, 1.75)InconclusiveLow
01 Leaving the study early for any reason (except relapse)Prien 1984ASIGN: 1+ Insufficient details on randomisationNoneMost recent episode not clearSparse/imprecise data (−1)3736RR= 1.7 (0.54, 5.32)InconclusiveLow
02 Leaving the study early due to side effectsPrien 1984ASIGN: 1+ Insufficient details on randomisationNoneMost recent episode not clearSparse/imprecise data (−1)3736RR= 2.92 (0.12, 69.43)InconclusiveLow

From: APPENDIX 23, EVIDENCE PROFILES

Cover of Bipolar Disorder
Bipolar Disorder: The Management of Bipolar Disorder in Adults, Children and Adolescents, in Primary and Secondary Care.
NICE Clinical Guidelines, No. 38.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2006.
Copyright © 2006, The British Psychological Society & The Royal College of Psychiatrists.

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