Table 49Summary of evidence profile for rapid tranquillisation in the management of acute behavioural disturbance

IM antipsychotic or benzodiazepine versus IM placeboIM antipsychotic versus IM antipsychoticIM antipsychotic versus benzodiazepine (versus combination)Oral antipsychotic + benzodiazepine versus IM antipsychotic + benzodiazepine
Evidence for efficacy (quality)Olanzapine (high), haloperidol (moderate) and lorazepam (high) effective versus placeboData are inconclusive (low) for efficacy outcomesOlanzapine more effective than lorazepam (high)No difference between two combinations (high)
Evidence for side effects (quality)Olanzapine has most favourable side-effect profile (low)Olanzapine has most favourable side-effect profile (high)Relevant side effects not reportedData are inconclusive (low) for tolerability/acceptability outcomes

From: 8, THE MEDICAL AND PHARMACOLOGICAL MANAGEMENT OF BIPOLAR DISORDER – PART I

Cover of Bipolar Disorder
Bipolar Disorder: The Management of Bipolar Disorder in Adults, Children and Adolescents, in Primary and Secondary Care.
NICE Clinical Guidelines, No. 38.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2006.
Copyright © 2006, The British Psychological Society & The Royal College of Psychiatrists.

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