Table 21Summary of study characteristics for organisational developments compared with standard care in the management of bipolar disorder

Multifaceted interventionMultifaceted intervention with telephone supportNurse-led careDrug therapy managementGuideline Implementation
No. trials (No. participants)5 RCTs (2829)3 RCTs (1440)3 RCTs (920)1 RCTs (125)4 RCTs (2573)
Study IDs
FINLEY2003
  1. ROLLMAN
  2. ROST
DiagnosisMajor depression
(2) Depression (diagnosis uncertain)
  1. Depression (diagnosis uncertain)
  2. 35% bipolar I; 65% bipolar II
(1) (3) Depression (diagnosis uncertain)
(2) 79% Major depressive disorder; 2% dysthymia
79% Major depressive disorder; 2% dysthymiaDepression (diagnosis uncertain)
SettingAll US apart from
  1. Chile
US(1) (3) UK
(2) US
USAll US apart from
  1. UK
Mean age
  1. 43
  2. 44
  3. 46
  4. 45
  5. 71
  1. 45
  2. 46
  3. 44
  1. 75
  2. 42
  3. 18–74
5441
Length of trial
  1. 6 months + 3 months follow-up
  2. 6 months
  3. 8 months
  4. 1 year
  5. 1 year
  1. 1 year
  2. 6 months
  3. 1 year
(1) 3 months
(2) (3) 6 months
6 months18 months
Intervention
  1. Psychoeducation, monitoring pharmacotherapy
  2. Psychoeducation
  3. Psychoeducation, pharmacotherapy
  4. Psychoeducation, pharmacotherapy
  5. Psychoeducation (later life depression), relapse prevention, support
  1. Psychoeducation, relapse prevention, telephone support
  2. Monitoring, telephone support
  3. Psychoeducation (groups), monitoring, telephone support, pharmacotherapy
  1. Weekly visits for 3 months, intervention negotiated by patient
  2. Weekly telephone support, encouraging self-management
  3. Regular contact with nurse
Clinical pharmacists monitored medication and provided telephone support
  1. Clinician interviewed to assess obstacles to implementation
  2. Clinician received advisory message at each clinic visit
  3. Clinician intervention training
  4. Clinician training in medication and therapy
Other(4) Cluster randomised - analysed separately(2) Cluster randomised – analysed separately; specifically excluded bipolar disorderAll cluster randomised

From: 7, THE PROCESS OF CARE AND PROVISION OF SERVICES IN THE MANAGEMENT OF BIPOLAR DISORDER – SPECIALIST SERVICES

Cover of Bipolar Disorder
Bipolar Disorder: The Management of Bipolar Disorder in Adults, Children and Adolescents, in Primary and Secondary Care.
NICE Clinical Guidelines, No. 38.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2006.
Copyright © 2006, The British Psychological Society & The Royal College of Psychiatrists.

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