Table 19Summary of study characteristics for EIS

Specific prevention intervention versus needs-based interventionFirst episode family intervention versus standard careFirst episode family intervention + individual intervention versus individual interventionEIS versus standard care
No. studies (No. participants)1 RCT (59)2 RCTs (630)1 RCT (76)2 RCTs (203)
Study IDMCGORRY2002
LINSZEN1996
  1. CRAIG2005 (LEO)
  2. KIUPERS2004
DiagnosisAt risk of progressing to first-episode psychotic disorder100% schizophrenia; first episode55% schizophrenia; 21% schizoaffective disorder; 24% other psychotic disorders
All first episode
Schizophrenia or related, first episode
(2) 6% bipolar
Mean age20
  1. 26
  2. 34
2126–28
InterventionLow-dose risperidone + CBT
  1. ACT enhanced with family involvement and social skills training, allocated case worker providing support and encouragement
  2. Group sessions every 3 months including discussion of illness management, importance of medication, life events, coping strategies
Individual therapy – education about illness, identifying prodromal signs, sources of stress and coping methods

Family therapy – psychoeducation, communication training, problem solving, role rehearsal and modelling
  1. Multidisciplinary team, AOT with extended hours, medication, CBT, family counselling and vocational strategies
  2. Medication review and monitoring, vocational and benefits help, information about psychosis, individual therapy for positive symptoms (CBT), family meetings, 24-hour crisis care – low case- load per team (<12) compared with comparator treatment (up to 35)
SettingUS; inpatients
  1. Denmark; in/out patients
  2. China
Holland; inpatientsUK; CMHT referrals
Follow-up12 months
  1. 2 years
  2. 18 months
1 and 5 years
  1. 18 months
  2. 12 months

From: 7, THE PROCESS OF CARE AND PROVISION OF SERVICES IN THE MANAGEMENT OF BIPOLAR DISORDER – SPECIALIST SERVICES

Cover of Bipolar Disorder
Bipolar Disorder: The Management of Bipolar Disorder in Adults, Children and Adolescents, in Primary and Secondary Care.
NICE Clinical Guidelines, No. 38.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2006.
Copyright © 2006, The British Psychological Society & The Royal College of Psychiatrists.

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