Quality Checklist for a Cohort Study*

Study ID:Relevant questions:
Guideline topic:
Checklist completed by:
SECTION 1: INTERNAL VALIDITY
In a well conducted cohort study:In this study the criterion is: (Circle one option for each question)
1.1The study addresses an appropriate and clearly focused question.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
SELECTION OF SUBJECTS
1.2The two groups being studied are selected from source populations that are comparable in all respects other than the factor under investigation.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.3The study indicates how many of the people asked to take part did so, in each of the groups being studied.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.4The likelihood that some eligible subjects might have the outcome at the time of enrolment is assessed and taken into account in the analysis.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.5What percentage of individuals or clusters recruited into each arm of the study dropped out before the study was completed?
1.6Comparison is made between full participants and those lost to follow-up, by exposure status.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
ASSESSMENT
1.7The outcomes are clearly defined.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.8The assessment of outcome is made blind to exposure status.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.9Where blinding was not possible, there is some recognition that knowledge of exposure status could have influenced the assessment of outcome.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.10The measure of assessment of exposure is reliable.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.11Evidence from other sources is used to demonstrate that the method of outcome assessment is valid and reliable.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.12Exposure level or prognostic factor is assessed more than once.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
CONFOUNDING
1.13The main potential confounders are identified and taken into account in the design and analysis.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
STATISTICAL ANALYSIS
1.14Have confidence intervals been provided?
SECTION 2: OVERALL ASSESSMENT OF THE STUDY
2.1How well was the study done to minimise the risk of bias or confounding, and to establish a causal relationship between exposure and effect?
Code ++, + or minus;
*

A cohort study can be defined as a retrospective or prospective follow-up study. Groups of individuals are defined on the basis of the presence or absence of exposure to a suspected risk factor or intervention. This checklist is not appropriate for assessing uncontrolled studies (for example, a case series where there is no comparison [control] group of patients).

From: APPENDIX 10, QUALITY CHECKLISTS FOR CLINICAL STUDIES AND REVIEWS

Cover of Antisocial Personality Disorder
Antisocial Personality Disorder: Treatment, Management and Prevention.
NICE Clinical Guidelines, No. 77.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © 2010, The British Psychological Society & The Royal College of Psychiatrists.

All rights reserved. No part of this book may be reprinted or reproduced or utilised in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers. Enquiries in this regard should be directed to the British Psychological Society.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.