Methadone maintenance treatment plus cognitive behavioural therapy (RP)

Quality assessment
No of studiesDesignLimitationsConsistencyDirectnessOther considerations
Abstinence from cocaine Rawson (2002)
1Randomised trialsNo limitationsNo important inconsistencySome uncertainty (−1)1Imprecise or sparse data (−1)2
Drug use (end of treatment) (Epstein 2003, UKCBTMM 2004)
2Randomised trialsNo limitationsNo important inconsistencyNo uncertaintyImprecise or sparse data (−1)4
Drug use (6–12 month follow up) (Epstein 2003, UKCTMM 2004)
1Randomised trialsNo limitationsNo important inconsistencyNo uncertaintyImprecise or sparse data (−1)2
Summary of findings
OutcomeNo of patientsEffectQuality
MMT + CBT (RP)MMT + ControlRelative (95% CI)Absolute (95% CI)
Abstinence from cocaine12/30 (40%)8/30 (26.7%)RR 1.50 (0.72 to 3.14)-⊕⊕○○
Low
Drug use (end of treatment)7076-SMD 0.12 (−0.28 to 0.52)⊕⊕ ⊕○
Moderate
Drug use (612 month follow up)7475-SMD 0.04 (−0.29 to 0.36)⊕⊕ ⊕○
Moderate
1

No UK studies

2

1 study

3

I-squared >50%

4

CIs compatible with benefit and no benefit

From: APPENDIX 16, EVIDENCE PROFILE TABLES

Cover of Drug Misuse
Drug Misuse: Psychosocial Interventions.
NICE Clinical Guidelines, No. 51.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2008.
Copyright © 2008, The British Psychological Society & The Royal College of Psychiatrists.

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