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Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet]. Chichester, UK: John Wiley & Sons, Ltd; 2003-.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet].

Interventions for the prevention of mastitis following childbirth

This version published: 2012; Review content assessed as up-to-date: August 08, 2012.

Link to full article: [Cochrane Library]

Plain language summary

Healthcare authorities and the World Health Organization recommend that newborn infants should exclusively be given breast milk until they are six months of age. Breastfeeding provides health benefits for the infant, including improved nutrition and protection against illnesses such as gastroenteritis, respiratory and ear infections, urinary tract infections, allergies and diabetes mellitus. Breastfeeding also saves on costs and has benefits for the mother. Mastitis is a significant complication of lactation and may stop some mothers from breastfeeding. The nipple becomes sore and the breast tender and swollen. If the nipple cracks, the breast can become infected and the mother may experience flu‐like symptoms. Poor breast attachment and inadequate emptying of milk from the breast when feeding may contribute to developing mastitis. It is important to investigate preventive measures in order to maintain and increase breastfeeding exclusivity and duration.

This review found five randomised controlled trials that involved a total of 960 women. They looked at a variety of preventive interventions including breastfeeding education, taking antibiotic medication, topical ointments and anti‐secretory factor cereal. None of the therapies made any difference in reducing breast infections or the length of breastfeeding exclusivity and duration with this limited evidence. Generally studies were of low quality, with limited findings highlighting the need for better quality research in this area.


Background: Despite the health benefits of breastfeeding, initiation and duration rates continue to fall short of international guidelines. Many factors influence a woman's decision to wean; the main reason cited for weaning is associated with lactation complications, such as mastitis.

Objectives: To assess the effects of preventive strategies for mastitis and the subsequent effect on breastfeeding duration.

Search methods: We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (8 August 2012).

Selection criteria: We included randomised controlled trials of interventions for preventing mastitis in postpartum breastfeeding women.

Data collection and analysis: We independently identified relevant studies and assessed the trial quality. We contacted trial authors for missing data and information as appropriate.

Main results: We included five trials (involving 960 women). In three trials of 471 women, we found no significant differences in the incidence of mastitis between use of antibiotics and no antibiotics (risk ratio (RR) 0.43; 95% confidence interval (CI) 0.11 to 1.61; or in one trial of 99 women comparing two doses (RR 0.38; 95% CI 0.02 to 9.18). We found no significant differences for mastitis in three trials of specialist breastfeeding education with usual care (one trial); anti‐secretory factor cereal (one trial); and mupirocin, fusidic acid ointment or breastfeeding advice (one trial).

Generally we found no differences in any of the trials for breastfeeding initiation or duration; or symptoms of mastitis.

Authors' conclusions: There was insufficient evidence to show effectiveness of any of the interventions, including breastfeeding education, pharmacological treatments and alternative therapies, regarding the occurrence of mastitis or breastfeeding exclusivity and duration. While studies reported the incidence of mastitis, they all used different interventions. Caution needs to be applied when considering the findings of this review as the conclusion is based on studies, often with small sample sizes. An urgent need for further adequately powered research is needed into this area to conclusively determine the effectiveness of these interventions.

Editorial Group: Cochrane Pregnancy and Childbirth Group.

Publication status: New search for studies and content updated (no change to conclusions).

Citation: Crepinsek MA, Crowe L, Michener K, Smart NA. Interventions for preventing mastitis after childbirth. Cochrane Database of Systematic Reviews 2012, Issue 10. Art. No.: CD007239. DOI: 10.1002/14651858.CD007239.pub3. Link to Cochrane Library. [PubMed: 23076933]

Copyright © 2012 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

PMID: 23076933

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