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Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet]. Chichester, UK: John Wiley & Sons, Ltd; 2003-.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet].

Surgery versus medication for treating acid reflux in brain‐damaged children having a feeding tube inserted

This version published: 2013; Review content assessed as up-to-date: October 23, 2012.

Link to full article: [Cochrane Library]

Plain language summary

Children with cerebral palsy often have oral motor impairment and need help with eating and drinking. Frequently this entails surgery to place a feeding tube (gastrostomy) directly into their stomach. They may also be found to have gastrooesophageal reflux (where stomach acid flows back up into the feeding tube (oesophagus)), which can be made worse by gastrostomy surgery. Reflux can be treated either with additional surgery at the same time as the gastrostomy (a fundoplication) or with antireflux medications. We carried out this review to determine which was the safest and most effective form of treatment. We found no randomised controlled trials that provided scientific evidence on which to base a conclusion, highlighting the need for a trial comparing the two interventions.

Abstract

Background: Children with neurological impairments frequently experience feeding difficulties, which can lead to malnutrition and growth failure. Gastrostomy feeding is now the preferred method of providing nutritional support to children with neurological impairments who are unable to feed adequately by mouth. Complications may arise as a result of gastrostomy placement, and the development or worsening of gastrooesophageal reflux (GOR) has been widely reported. This has led to the frequent use of surgical antireflux treatment in the form of a fundoplication, or other antireflux procedures. Fundoplication is associated with a high recurrence rate, surgical failure, and significant morbidity and mortality.

Since proton pump inhibitors (PPIs) were introduced in the 1990s, they have come to play a larger part in the medical management of GOR in children with neurological impairments. Uncontrolled studies suggest that PPIs may be a safe, appropriate treatment for GOR. Other agents currently used include milk thickeners, acid suppression drugs, acid buffering agents, gut motility stimulants and sodium alginate preparations.

There are risks and benefits associated with both surgical and medical interventions and further comparison is necessary to determine the optimal treatment choice.

Objectives: To compare the effectiveness of antireflux surgery and antireflux medications for children with neurological impairments and GOR who are undergoing placement of a gastrostomy feeding tube.

Search methods: We searched the following databases on 23 March 2012: the Cochrane Central Register of Controlled Trials (CENTRAL), Ovid MEDLINE, EMBASE, CINAHL, LILACS and ISI Web of Science. Previously, we searched the Child Health Library in June 2009. We also performed online searches of trial registries, medical journals, conference proceedings, dissertations and theses. We contacted specialists in the medical and industry setting for knowledge of completed or ongoing trials.

Selection criteria: We sought to include randomised controlled trials that recruited children up to the age of 18 years with neurological impairments and GOR who were undergoing gastrostomy tube insertion.

Data collection and analysis: The review authors worked independently to select trials; none were identified.

Main results: We identified no trials that satisfied the criteria for this review.

Authors' conclusions: There remains considerable uncertainty regarding the optimal treatment when faced with the decision of fundoplication surgery versus antireflux medications for children with GOR and neurological impairment who are undergoing gastrostomy insertion. There is a need for robust scientific evidence in order to provide data on the comparable risks or benefits of the two interventions.

Editorial Group: Cochrane Developmental, Psychosocial and Learning Problems Group.

Publication status: New search for studies and content updated (no change to conclusions).

Citation: Vernon‐Roberts A, Sullivan PB. Fundoplication versus postoperative medication for gastro‐oesophageal reflux in children with neurological impairment undergoing gastrostomy. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD006151. DOI: 10.1002/14651858.CD006151.pub3. Link to Cochrane Library. [PubMed: 23986351]

Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

PMID: 23986351

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