Table C12Base case drug efficacy inputs

Weighted mean difference % change in HbA1cChange in TC:HDL*Change in SBP
Biphasic analogue vs human insulin−0.0200
Glargine vs human insulin0.0400
Glargine vs biphasic analogue0.4300
Exenatide vs glargine0.08−0.12−3.58
Exenatide vs biphasic analogue−0.090.1−6.22
Rosiglitazone vs glargine0.150.420
Pioglitazone vs rosiglitazone−0.1−1.080

Calculations for the change in TC:HDL are shown in tables 52 to 54 at the end of this appendix. Conversion rate of mg/dl to mmol/l=0.0259.410

From: Appendix C, Health economic analysis of third-line therapy with insulins, glitazones or exenatide in Type 2 diabetes

Cover of Type 2 Diabetes
Type 2 Diabetes: National Clinical Guideline for Management in Primary and Secondary Care (Update).
NICE Clinical Guidelines, No. 66.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

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