Question IDQuestion wordingStudy type filters usedDatabase and years
PAT 1Are patient education models effective for people with Type 2 diabetes?All study typesMedline 2002–2006
Embase 2002–2006
Cochrane 2002–2006
CINAHL 2002–2006
DIET 1Which forms of dietary advice are effective treatments for people with Type 2 diabetes?All study typesMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
TARG 2In people with Type 2 diabetes, what should be the target value for HbA1c?Systematic reviews, RCTs and observational studiesMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
MET 1Is metformin as monotherapy or in combination with oral antidiabetic drugs effective in the control of blood glucose in people with Type 2 diabetes compared to other oral antidiabetic drugs regimens or placebo?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
SEC 1Are the insulin secretagogues (sulphonylureas and nateglinide and repaglinide) as monotherapy or in combination with oral antidiabetic drugs effective in the control of blood glucose in people with Type 2 diabetes compared to other oral antidiabetic drugs regimens or placebo?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
GLIT 1Are the glitazones (pioglitazone and rosiglitazone) effective in the control of blood glucose in people with Type 2 diabetes either alone or in combination compared to other antidiabetic treatment regimens?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
ACAR 1Are the alphaglucosidases inhibitors (acarbose or miglitol) as monotherapy or in combination with oral antidiabetic drugs effective in the control of blood glucose in people with Type 2 diabetes compared to other oral antidiabetic drugs regimens or placebo?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
EXEN 1Is exenatide effective in the control of blood glucose in people with Type 2 diabetes either alone or in combination compared to other antidiabetic treatment regimens?Systematic reviews and RCTsMedline 1966–2007
Embase 1980–2007
Cochrane 1800–2007
CINAHL 1982–2007
INS 2Are the biphasic insulin preparations (premixes) effective in the control of blood glucose compared to NPH in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
INS 3Are the biphasic human insulin preparations effective in the control of blood glucose compared to biphasic analogue preparations in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
INS 4Are multiple analogue insulin injection regimens effective (meal time and basal insulin) compared to basal insulin or biphasic insulin regimes?All study typesMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
INS 5Are long acting insulin analogues (insulin glargine (Lantus®) effective in the control of blood glucose compared to NPH insulin, biphasic insulins or multiple daily injections?Systematic reviews and RCTsMedline 2002–2007
Embase 2002–2007
Cochrane 2002–2007
CINAHL 2002–2007
INS 6Is insulin in combination with oral antidiabetic drugs effective in the control of blood glucose compared to insulin alone in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
INS 7What methods of delivery of insulin therapy are effective at improving clinical outcomes in Type 2 diabetes?All study typesMedline 1995–2007
Embase 1995–2007
Cochrane 1995–2007
CINAHL 1995–2007
SM 1Is self-monitoring effective for blood glucose control in patients with Type 2 diabetes?Systematic reviews, RCTs and qualitative studiesMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
BP 1In people with Type 2 diabetes (with and without nephropathy), what should be the target value for blood pressure?Systematic reviews, RCTs and observational studiesMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
ACE 1Are ACE inhibitors (alone or in combination) effective in the lowering of blood pressure and/or reduction of cardiovascular disease compared with other treatments in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
ALPH 1Are alpha blockers (alone or in combination) effective in the lowering of blood pressure and/or reduction of cardiovascular disease compared with other treatments in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
ANG 1Are angiotensin II receptor antagonists (alone or in combination) effective in the lowering of blood pressure and/or reduction of cardiovascular disease compared with other treatments in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
BETA 1Are beta blockers (alone or in combination) effective in the lowering of blood pressure and/or reduction of cardiovascular disease compared with other treatments in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
CALC 1Are dihydropyridine and non-dihydropyridine calcium channel blockers (alone or in combination) effective in the lowering of blood pressure and/or reduction of cardiovascular disease compared with other treatments in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
THIA 1Are thiazide and loop diuretics (alone or in combination) effective in the lowering of blood pressure and/or reduction of cardiovascular disease compared with other treatments in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
TARG 1In people with Type 2 diabetes, what should be the target value for lipid levels?All study typesMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
STAT 1Are statins effective in improving lipid profiles and other outcomes compared to other treatments or placebo in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
FIB 1Are fibrates effective in improving lipid profiles and other outcomes compared to other treatments or placebo in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
NICO 1Are nicotinic acid derivatives effective in improving lipid profiles and other outcomes compared to other treatments or placebos in people with Type 2 diabetes?Systematic reviews and RCTsMedline 1966–2007
Embase 1980–2007
Cochrane 1800–2007
CINAHL 1982–2007
OMEG 1Are omega 3s (fish oils) effective in improving lipid profiles and other outcomes compared to other treatments or placebo in people with Type 2 diabetes?Systematic reviews and RCTsMedline 1966–2007
Embase 1980–2007
Cochrane 1800–2007
CINAHL 1982–2007
AMED 1985–2007
RISK 1Which arterial risk tables, equations or engines for calculation of arterial risk are most predictive of arterial disease in people with Type 2 diabetes?Systematic reviews, RCTs and observational studiesMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
PREV 1Does aspirin prevent vascular disease in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
PREV 2Does clopidogrel prevent vascular disease in people with Type 2 diabetes compared to aspirin or in combination with aspirin?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
NEPH 1Which tests should be used in the diagnosis and management of renal disease?Systematic reviews, RCTs and observational studiesMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
NEUR 1Are tricyclic drugs effective for the treatment of painful neuropathy in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
NEUR 2Is gabapentin effective for the treatment of painful neuropathy in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
NEUR 3Is pregabalin effective for the treatment of painful neuropathy in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
NEUR 4Is carbamazepine effective for the treatment of painful neuropathy in people with Type 2 diabetes?Systematic reviews and RCTsMedline 2001–2007
Embase 2001–2007
Cochrane 2001–2007
CINAHL 2001–2007
GAST 1In people with Type 2 diabetes, can gastroparesis be effectively treated with a prokinetic drug (metoclopramide or domperidone)?Systematic reviews and RCTsMedline 1966–2007
Embase 1980–2007
Cochrane 1800–2007
CINAHL 1982–2007
EREC 1Are PDE5 inhibitors effective for the treatment of erectile dysfunction in people with Type 2 diabetes?Systematic reviews and RCTsMedline 1966–2007
Embase 1980–2007
Cochrane 1800–2007
CINAHL 1982–2007

From: Appendix A, Clinical questions and search strategies

Cover of Type 2 Diabetes
Type 2 Diabetes: National Clinical Guideline for Management in Primary and Secondary Care (Update).
NICE Clinical Guidelines, No. 66.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

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