Table 60Placebo-control trials of exenatide: Summary of meta-analyses

Exenatide dosageOutcomeNHeterogeneity
MeasureEstimate95% CIP valueI2p
10 mcg BIDTotal WDs9aRR1.14(0.83; 1.56)0.41564%0.005
WDs due to AE9aRR3.18(1.70; 5.93)<0.00139%0.106
5 mcg BIDTotal WDs5bRR0.77(0.56; 1.06)0.10637%0.174
WDs due to AE5bRR1.76(0.98; 3.19)0.0580%0.557
10 mcg BIDHypoglycemia, any8cRR2.96(1.81; 4.84)<0.00163%0.009
Nausea9aRR3.43(2.20; 5.34)<0.00176%<0.001
Vomiting8dRR4.28(2.38; 7.72)<0.00138%0.128
Diarrhea7eRR2.29(1.60; 3.27)<0.0010%0.913
Upper respiratory tract infection4fRR0.87(0.63; 1.21)0.4140%0.672
Headache5gRR1.23(0.78; 1.92)0.3730%0.859
5 mcg BIDHypoglycemia, any5bRR2.27(1.20; 4.27)0.01152%0.081
Nausea5bRR2.42(1.47; 4.16)0.00165%0.001
Vomiting5bRR3.55(2.16; 5.83)<0.0010%0.912
Diarrhea5bRR1.74(1.13; 2.67)0.0110%0.433
Upper respiratory tract infection3hRR0.79(0.44; 1.39)0.41141%0.184
Headache3iRR1.81(1.10; 2.97)0.0190%0.593

Abbreviations: AE, adverse event; BID, twice daily; CI, confidence interval; FPG, fasting plasma glucose; RR, relative risk; WD, withdrawal; WMD, weighted mean difference.

a

Studies included in analysis: Buse (2004), DeFronzo (2005), Kendall (2005), Zinman (2007), Moretto (2008), Gao (2009), Kadowaki (2009), Gill (2010), Apovian (2010).

b

Studies included in analysis: Buse (2004), DeFronzo (2005), Kendall (2005), Moretto (2008), Kadowaki (2009).

c

Studies included in analysis: Studies included in analysis: Buse (2004), DeFronzo (2005), Kendall (2005), Zinman (2007), Moretto (2008), Gao (2009), Kadowaki (2009), Gill (2010).

d

Studies included in analysis: Buse (2004), DeFronzo (2005), Kendall (2005), Zinman (2007), Moretto (2008), Gao (2009), Kadowaki (2009), Apovian (2010).

e

Studies included in analysis: Buse (2004), DeFronzo (2005), Kendall (2005), Zinman (2007), Moretto (2008), Gao (2009), Kadowaki (2009).

f

Studies included in the analysis: DeFronzo (2005), Kendall (2005), Moretto (2008), Gao (2009).

g

Studies included in analysis: Buse (2004), Kendall (2005), Zinman (2007), Moretto (2008), Gao (2009).

h

Studies included in analysis: DeFronzo (2005), Kendall (2005), Moretto (2008).

i

Studies included in analysis: Buse (2004), Kendall (2005), Moretto (2008).

From: Results

Cover of Drug Class Review: Newer Diabetes Medications, TZDs, and Combinations
Drug Class Review: Newer Diabetes Medications, TZDs, and Combinations: Final Original Report [Internet].
Jonas D, Van Scoyoc E, Gerrald K, et al.
Portland (OR): Oregon Health & Science University; 2011 Feb.
Copyright © 2011, Oregon Health & Science University.

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