| Combination multitreatment | Marlin (1998)210
n=71 | | | | | Employment status:
Greater number of participants returned to work in treatment group (significance not reported) | 49/71 were not followed up. The authors do not report on adverse effects | 3 (NB controlled trial) |
| Multitreatment (including supplements) | Teitelbaum (2001)215 | | Symptoms, response, fibromyalgia impact qre:
significant differences in favour of treatment group (p=0.0002) | | | | One patient in each group dropped out because of side effects and one in each group for reasons not reported. 24 reported adverse events in treatment group, 22 in placebo group | 19 |
| Broad-based management | Goudsmit (1996)211
n=52 | | | Uncertainty, self-efficacy: Improvement in self-efficacy in intervention group compared to control group (p=0.13)
Anxiety and depression: No significant differences between groups. | | Symptoms:
Significant improvement in intervention groups compared to control group in fatigue (p=0.03) and somatic symptoms (p=0.04).
No significant differences between groups for cognitive difficulty.
Functional impairment: No significant differences between groups.
Coping: No significant differences between groups. | Eight excluded from analysis: 3 in intervention group and 5 controls. Two wishes to discontinue treatment: not stated from which group.
9% of intervention group and 18% of controls ‘felt worse’ at the end of the study. | 3 (NB controlled trial) [Revised validity after guidelines stakeholder consultation] |
| Buddy/mentor programme | Schlaes (1996)212
n=12 | | Fatigue severity: greater improvement in treatment group compared to control (p<0.03) | Positive thinking,, depression, psychological distress, perceived stress, coping strategies, perceived social support: no significant differences between groups | | | 2 dropped out, one in each group, could not complete post-test measures due to severity of illness. | 4 (NB controlled trial) |
| Group therapy | Soderberg (2001)213
n=14 | | Fatigue: results not reported | | | Quality of life: comparisons were not made between groups | One withdrawal in control group | 1 |
| Low sugar low yeast diet | Hobday (2005, unpublished)214
n=57 | | Fatigue: no significant differences between groups | Anxiety, depression: no significant differences between groups | | General health: no significant differences between groups | 8 in the LSLY arm and 9 in the control arm were lost to follow-up | 11 |
