Table 7.15Withdrawals

StudyOutcomesFollow-upResult – best treatment
COBRA study253,254
Level 1++
Total number of withdrawals (8% vs 29%), withdrawals due to AEs (3% vs 8%) and due to lack of efficacy (5% vs 15%)56 weeksAggressive (better)
CIMESTRA study246,247
Level 1++
Withdrawals due to SAEs (N=1, 1% vs N=3, 4%)2 yearsSimilar

From: 7, Pharmacological management

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Rheumatoid Arthritis: National Clinical Guideline for Management and Treatment in Adults.
NICE Clinical Guidelines, No. 79.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2009, Royal College of Physicians of London.

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