Table 34Incidence of tardive dyskinesia with olanzapine and risperidone in longer-term studies

Drug durationNMean dose (mg/d)Baseline rate of tardive dyskinesiaIncidence (new-onset cases)
Olanzapine compared with risperidone and immediate-release quetiapine
Intercontinental
SOHO 2004
6 months
5833Olanzapine 11
Quetiapine 340
Risperidone 4
6% to 8%Olanzapine 1%, quetiapine 2%, risperidone 3%
Olanzapine vs. risperidone, P<0.001
European SOHO
2009
3 years
4939Clozapine 259
Olanzapine 12
Quetiapine 437
Risperidone 5
9%New onset: olanzapine 1.7%, risperidone 2.7%, quetiapine 1.3%, clozapine 3.3%
Prevalence tardive dyskinesia: risperidone vs. olanzapine, 1.70 (95% CI, 1.35 to 2.14)

From: Results

Cover of Drug Class Review: Atypical Antipsychotic Drugs
Drug Class Review: Atypical Antipsychotic Drugs: Final Update 3 Report [Internet].
McDonagh M, Peterson K, Carson S, et al.
Portland (OR): Oregon Health & Science University; 2010 Jul.
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