Evidence Table 24Quality assessment of randomized controlled trials in pediatrics with bipolar disorder

Author, Year CountryRandomization adequate?Allocation concealment adequate?Groups similar at baseline?Eligibility criteria specified?Outcome assessors masked?Care provider masked?Patient masked?Reporting of attrition, crossovers, adherence, and contaminationLoss to follow-up: differential/highMaintenance of comparable groupsIntention-to-treat (ITT) analysisFundingQuality rating
Biederman 2005NRN/AYesYesOpen-labelOpen-labelOpen-labelYes, No, No, NoDifferential: Yes High: NoUnclearYesCenter grant from the Stanley Medical Research InstituteFair
DelBello 2002Unclear, used random number generatorUnclearYesYesYesYesYesYes, No, No, NoDifferential: Yes High: NoUnclearYesAstraZenecaFair
Delbello 2009Unclear, used random number generatorNRYesYesYesYesYesYes, No, No, NoNo/NoYesYesAstraZeneca PharmaceuticalsFair
Findling 2009NRNRUnclear
Missing data on some clinical chartactoristics. Reported data shows differences in age, % non-Hispanic/Latino, % without psychotic features,% without ADHD
YesNR (described as double-blind)NR (described as double-blind)YesYes, No, Yes, NoNo/NoYesNoOtsuka Pharmaceutical Co., Ltd.Fair
Haas 2009NRNRYesYesNR (described as double-blind)NR (described as double-blind)NR (described as double-blind)Yes, No, Yes, NoNo/NoYesNo 169/170 includedJohnson & Johnson Pharmaceutical Research and Development, LLC.Fair
Tohen 2007NRNRYesYesNR (described as double-blind)NR (described as double-blind)NR (described as double-blind)Yes, No, No, No79.4% compeleted olanzapine group 64.8% completed placebo groupUnclearYesEli Lilly & Co.Fair
Tramontina 2009YesYesMostly: SES was significantly different, placebo group having more in the upper middle than aripiprazoleYesYesYesYesYes, No, No, NoNo/NoYesYesBristol-Myers SquibbGood

From: Evidence Tables

Cover of Drug Class Review: Atypical Antipsychotic Drugs
Drug Class Review: Atypical Antipsychotic Drugs: Final Update 3 Report [Internet].
McDonagh M, Peterson K, Carson S, et al.
Portland (OR): Oregon Health & Science University; 2010 Jul.
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