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McDonagh M, Peterson K, Carson S, et al. Drug Class Review: Atypical Antipsychotic Drugs: Final Update 3 Report [Internet]. Portland (OR): Oregon Health & Science University; 2010 Jul.

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

Evidence Tables

Evidence Table 1. Head-to-head trials in patients with schizophrenia

Evidence Table 2. Quality assessment of trials in patients with schizophrenia

Evidence Table 3. Randomized controlled trials in patients with first-episode schizophrenia

Evidence Table 4. Systematic reviews of trials in patients with schizophrenia

Evidence Table 5. Placebo-controlled trials in patients with schizophrenia

Evidence Table 6. Observational studies of safety and adverse events in patients with schizophrenia

Evidence Table 7. Quality assessment of observational studies in patients with schizophrenia

Evidence Table 8. Randomized controlled trials in patients with bipolar I disorder

Evidence Table 9. Quality assessment of randomized controlled trials of patients with bipolar disorder

Evidence Table 10. Observational studies in patients with bipolar disorder

Evidence Table 11. Quality assessment of observational studies in patients with bipolar disorder

Evidence Table 12. Systematic reviews of atypical antipsychotics in patients with behavioral and psychological symptoms of dementia

Evidence Table 13. Head-to-head trials in patients with behavioral and psychological symptoms of dementia

Evidence Table 14. Quality assessment of trials in patients with behavioral and psychological symptoms of dementia

Evidence Table 15. Active-control trials in patients with behavioral and psychological symptoms of dementia

Evidence Table 16. Placebo-controlled trials in patients with behavioral and psychological symptoms of dementia

Evidence Table 17. Observational studies in patients with behavioral and psychological symptoms of dementia

Evidence Table 18. Quality assessment of observational studies in patients with behavioral and psychological symptoms of dementia

Evidence Table 19. Systematic reviews of atypical antipsychotics in youths

Evidence Table 20. Active-control trials of atypical antipsychotics in youths

Evidence Table 21. Quality assessment of trials in youths

Evidence Table 22. Placebo-controlled trials in youths

Evidence Table 23. Randomized controlled trials in patients with bipolar I disorder

Evidence Table 24. Quality assessment of randomized controlled trials in pediatrics with bipolar disorder

Evidence Table 25. Randomized controlled trials of patients with major depressive disorder

Evidence Table 26. Quality assessment of randomized controlled trials of patients with major depressive disorder

Evidence Table 27. Observational studies in patients with major depressive disorder

Evidence Table 28. Quality assessment of observational studies in major depressive disorder

Evidence Table 29. Trials in adolescent schizophrenia

Evidence Table 30. Observational studies in youths

Evidence Table 31. Quality assessment of observational studies in youths

Evidence Table 32. Systematic reviews in bipolar disorder

AAP

Atypical Antipsychotic

ABC

Aberrant Behavior Checklist

ACT

Active-control trial

AD

Alzheimer’s Disease

ADHD

Attention deficit hyperactive disorder

ADI-R

Autism Diagnostic Interview-Revised

AE

Adverse event

AIMS

Abnormal Involuntary Movement Scale

ALT

Alanine aminotransferase

AMDP-5

Association for Methodology and Documentation in Psychiatry adverse event questionnaire

ANCOVA

Analysis of covariance

ANOVA

Analysis of variance

ASD

Autism spectrum disorders

ASEX

Arizona Sexual Experience Scale

AST

Aspartate aminotransferase

BARS

Barnes Akathisia Rating Scale

BAS

Behavioral Approach System scale

BEHAVE-AD

Behavioral Pathology in Alzheimer’s Disease

bid

Twice daily

BIS

Behavioral Inhibition System scale

BMI

Body mass index

BNT

Boston Naming Test

BPAD

Empirical Behavioral Pathology in Alzheimer’s Disease scale

BPRS

Brief Psychiatric Rating Scale

BRMS

Bech Rafaelsen Melancholia Scale

BWISE

Body weight, image and self-esteem evaluation questionnaire

CBCL

Child Behavior Checklist

CCT

Controlled clinical trial

CDI

Children’s Depression Inventory scale

CDSS

Calgary Depression Scale for Schizophrenia

CERAD

Consortium to Establish a Registry for Alzheimer’s Disease

CGI

Clinical global impressions (S, C and I versions)

CGI-I

Clinical global impression scale - Improvement

CGI-S

Clinical global impression scale - Severity

CI

Confidence interval

CMAI

Cohen-Mansfield Agitation Inventory

CMMSE

Cantonese version of Mini-Mental State Examination

CNS

Central nervous system

COGLAB

COGnitive LABoratory (computer-assisted cognitive test battery)

COPD

Chronic obstructive pulminary disease

COSTART

US FDA Coding Symbols for a Thesaurus of Adverse Reaction Terms

CPM

Concomitant psychotropic medication

CPRS

Conners Parent Rating Scale

CPT

Continuous Performance Test

CR

Controlled release

CSFQ

Changes in Sexual Functioning Questionnaire

CSQ-8

Client Satisfaction Questionnaire-8

CTD

Cognitive Test for Delirium

CUAD

Chemical Use, Abuse, and Dependence Scale

CV

Cardiovascular

CVA

Cerebrovascular accident

CVLT

California Verbal Learning Test

CVS

Cardiovascular system

d

Day

DAI

Drug Attitude Inventory

DAS

Disability Assessment Schedule

DB

Double-blind

DIEPSS

Drug-induced Extrapyramidal Symptom Scale

DIS III

Diagnostic Interview Schedule III

DISCUS

Dyskinesia Identification System Condensed User Scale

dL

Deciliter

DOTES

Dosage Record and Treatment Emergent Symptom Scale

DSDT

digit span distraction test

DSM-III

Diagnostic and Statistical Manual of Mental Disorders-Third Edition

DSM-IV

Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition

DVP

Digital volume pulse

E-BEHAVE-ED

Empirical Behavioral Pathology in Alzheimer’s Disease Rating Scale

ECG

Electrocardiogram

ECT

Electroconvulsive therapy

EEG

Electroencephalogram

EF

Ejection fraction

EPS

Extrapyramidal symptoms

ER

Extended release

ESRS

Extrapyramidal Symptom Rating Score

FAST

Functional Assessment Staging Rating Scale

FDA

US Food and Drug Administration

FGIR

Final Global Improvement Rating

FU

Follow-up

g

Gram

GAF

Global Assessment of Functioning Scale

GAS score

Global Assessment Scale Score

GBAS

General Behavior Assessment Scale

GI

Gastrointestinal

GP

General practitioner

GPS

General Psychopathology Subscale

h

Hour

HAM-D

Hamilton Depression Scale

HAS

Hamilton Anxiety Scale

HDI

Hamilton Depression Inventory

HDL-C

High density lipoprotein cholesterol

HMO

Health maintenance organization

HOMA

Homoeostasis model assessment index

HPL

Hyperprolactinemia

HR

Hazard ratio

HRQOL

Health related quality-of-life

ICD-10

International Classification of Diseases, Tenth Revision

ICD-9

International Classification of Diseases, Ninth Revision

IDS-C

Inventory of Depressive Symptomatology-Clinician Rated

INS

Insulin

IR

Immediate release

IRI

Insulin resistance index

ISST

Information-Seeking Skills Test

ITT

Intention-to-treat

L

Liter

LA

Long acting

LDL-C

Low-density lipoprotein cholesterol

LFT

Liver function test

Li

Lithium

LOCF

Last Observation Carried Forward

LQL

Lehman Quality of Life

LS means

Least squares means

MADRS

Montgomery-Asberg Depression Rating Scale

MANCOVA

Multivariate analysis of covariance

MASC

Multidimensional Anxiety Scale for Children

mcg

Microgram

MDB

Movement Disorder Burden

MDD

Major depressive disorder

MDE

Major depressive episode

mg

Milligram

min

Minute

MINI

Mini International Neuropsychiatric Interview

MITT

Mother-Infant Treatment Team

mL

Milliliter

MLDL

Munich List of Quality-of-Life Dimensions

MMSE

Mini-Mental State Examination

mo

Month

MOSES

Multidimensional Observational Scale for Elderly Subjects

MSQ

Medication Satisfaction Questionnaire

N

Sample size (entire sample)

n

Subgroup sample size

NA

Not applicable

NAART-R

North American Adult Reading Test-Revised

NINCDS-ADRDA

National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer’s Disease and Related Disorders Association

NINDS-AIREN

National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et l’Enseignement en Neurosciences

NIP

National Institute of Psychiatry

NMS

Neuroleptic malignant syndrome

NOSGER

Nurses’ Observation Scale for Geriatric Patients

NOSIE

Nurses’ Observation Scale for Inpatient Evaluation

NPI

Neuropsychiatric Inventory

NPI-NH

Neuropsychiatric Inventory-Nursing Home

NR

Not reported

NRS

Neurologic Rating Scale

NS

Not significant

NSA

Negative Symptom Assessment

NSD

No significant difference

OAS

Overt Aggression Scale

OAS-M

Modified Overt Aggression Scale

OR

Odds ratio

P

P value

P

Placebo

PANSS

Positive and Negative Syndrome Scale

PANSS-D

PANSS Depression Cluster

PANSS-EC

Positive and Negative Syndrome Scale-Excited Component

PCT

Placebo-controlled trial

PDD

Pervasive developmental disorder

PDD-NOS

Pervasive developmental disorder - not otherwise specified

PDS

Progressive Deterioration Scale

PEAT

Penn Emotional Acuity Test

PETiT

Personal Evaluation of Transitions in Treatment

PGDRS

Psychogeriatric Dependency Rating Scale

PGWB

Psychological General Well-Being

PPR

Positive Psychopathology Rating

PPY

Per person year

PRAEQ

Prolactin Related Adverse Event Questionnaire

PSP scale

Personal and Social Performance scale

PSQI

Pittsburgh Sleep Quality Index

Q-LES-Q

Quality of Life Enjoyment and Satisfaction Questionnaire

qd

Once daily

QLDS

Quality-of-Life in Depression Scale

QLI

Lehman Brief Quality-of-Life Interview

QOL

Quality-of-life

QUALID

Quality-of-Life in Late-Stage Dementia scale

RAAP

Rating of Aggression Against People and/or Property Scale

RAVLT

Rey Auditory Verbal Learning Task

RBANS

Repeatable Battery for the Assessment of Neuropsychological Status

RCT

Randomized controlled trial

RDQ

Reflux Disease Questionnaire

RFS

Role Functioning Scale

RODOS-UK

UK Risperidone Olanzapine Drug Outcomes Studies in Schizophrenia Program

RR

Relative risk

SADS-CB

Schedule for Affective Disorders and Schizophrenia-Change Bipolar Scale

SAFE

Social Adaptive Functioning Evaluation

SAGE

Systematic Assessment of Geriatric drug use via Epidemiology

SANS

Scale for Assessment of Negative Symptoms

SAPS

Scale for the Assessment of Positive Symptoms

SAR-S

Simpson Angus Rating Scale for Extrapyramidal Side Effects

SAS

Social Adjustment Scale

SB

Single-blind

SCID

Structural Clinical Interview for DSM-IV

SD

Standard deviation

SE

Standard error

SFS

Social Functioning Scale

SIP

Sickness Impact Profile

SMB

Suicide Monitoring Board

SOFA

Social and Occupational Functioning Assessment

SOT

Standard olanzapine tablets

SR

Sustained release

SSPA

Social Skills Performance Assessment

SSRI

Selective serotonin reuptake inhibitor

SSTICS

Subjective Scale to Investigate Cognition in Schizophrenia

SUD

Substance use disorder

SVLT

Serial Verbal Learning Test

SWMT

Spatial Working Memory Test

SWN

Subjective Well-being under Neuroleptic Treatment Scale

SWS

Slow-wave sleep

TA

Typical Antipsychotic drugs (e.g. haloperidol, perphenazine)

TAS

Total Aggression Severity

TC

Total cholesterol

TD

Tardive dyskinesia

TEAEs

Treatment emergent adverse events

TESS

Treatment Emergent Symptom Scale

tid

Three times daily

TMT

Trail Making Test

TNR

Treatment nonresponsive

ToL test

Tower of London test

UKU-SERS

Udvalg for Kliniske Undersogelser Side Effect Rating Scale

VAS

Visual analog scale

vs.

Compared with (versus)

WAIS-R

Wechsler Adult Intelligence Scale - Revised

WCST

Wisconsin Card Sorting Test

WD

Withdrawal

WHO

World Health Organization

WHO-QL

World Health Organization - Quality-of-Life

WHR

Waist-hip circumference ratio

WISC-R

Wechsler Intelligence Scales for Children - Revised

WMS-R

Wechsler Memory Scale - Revised

XR

Extended release

y

Year

Y-BOCS

Yale-Brown Obsessive-Compulsive Scale

YMRS

Young Mania Rating Scale

Copyright © 2010 by Oregon Health & Science University, Portland, Oregon 97239. All rights reserved.
Cover of Drug Class Review: Atypical Antipsychotic Drugs
Drug Class Review: Atypical Antipsychotic Drugs: Final Update 3 Report [Internet].
McDonagh M, Peterson K, Carson S, et al.
Portland (OR): Oregon Health & Science University; 2010 Jul.

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