Table 4Head-to-head trials in adults with urticaria

Author
Year
Condition
Quality
Drug, dosage
Number of subjects
Duration
Results
Cetirizine compared with fexofenadine
Handa 200475
Fair
Cetirizine 10 mg qd
Fexofenadine 180 mg qd
116
4 weeks
Cetirizine vs. fexofenadine
Symptom-free at endpoint: 51.9% vs. 4.4%
Partial improvement at endpoint: 36.5% vs. 42.2%
No improvement at endpoint: 11.5% vs. 53.3%
P=NR
Cetirizine compared with levocetirizine
Garg 200773
Fair
Cetirizine 10 mg
Levocetirizine 5 mg
30
6 weeks
Cetirizine vs. levocetirizine (N)
Wheal response 30 vs. 28
Flare response 30 vs. 30
Itch response 30 vs. 9
Cetirizine compared with loratadine
Guerra et al
199474
Fair
Cetirizine 10 mg
Loratadine 10 mg
Placebo
116
4 weeks
Significant (P<0.01) loratadine vs. cetirizine on days 3, 14, 28 (NS on day 7)
Day 3/7/14/28:
Loratadine: −23%/ −46%/ −65%/ −81%
Cetirizine: −35%/ −50%/ −60%/ −69%
Placebo: −19%/ −23%/ −34%/ −55%
Response rate (symptom-free):
Loratadine 63% vs. cetirizine 45%; NSD
Placebo 13%
Thomas 199877
Fair
Cetirizine 10 mg
Loratadine 10 mg
202
4 weeks
Data reported in graphs
Loratadine vs. cetirizine
The number, size, and the duration of lesions (P<0.05)
Fall in the mean score of pruritus (P<0.05)
Levocetirizine compared with desloratadine
Potter 200976
Fair
Levocetirizine 5 mg
Desloratadine 5 mg
886
4 weeks
Levocetirizine vs. desloratadine
Pruritus severity score
First treatment week 1.02 (0.04) vs. 1.18 (0.04); P<0.001
Entire treatment period 0.86 (0.04) vs. 0.99 (0.04); P=0.004
Chronic idiopathic urticaria composite score
First treatment week 1.98 (0.08) vs. 2.23 (0.08); P=0.005
Entire treatment period 1.71 (0.07) vs. 1.88 (0.07); P=0.041

Abbreviations: NR, not reported; NS, not significant; NSD, no significant difference; qd, once daily.

From: Results

Cover of Drug Class Review: Newer Antihistamines
Drug Class Review: Newer Antihistamines: Final Report Update 2 [Internet].
Carson S, Lee N, Thakurta S.
Portland (OR): Oregon Health & Science University; 2010 May.
Copyright © 2010 by Oregon Health & Science University, Portland, Oregon 97239. All rights reserved.

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