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Drug Class Review: Newer Antihistamines: Final Report Update 2 [Internet]

Drug Class Review: Newer Antihistamines: Final Report Update 2 [Internet]

Drug Class Reviews - Oregon Health & Science University

Version: May 2010

Results

Literature searches for Update 2 identified 1754 new citations. We received dossiers from the manufacturers of azelastine, desloratadine, and levocetirizine. By applying the eligibility and exclusion criteria to titles and abstracts of all identified citations, we obtained full-text copies of 140 citations. After re-applying the criteria for inclusion, we ultimately included 61 publications, representing 58 unique studies. See Appendix D for a list of excluded studies and reasons for exclusion at this stage. Figure 1 shows the flow of study selection.

Summary of the Evidence

Results of this review are summarized in Table 6.

Methods

Seasonal allergic rhinitis

Introduction

Antihistamines inhibit the effects of histamine at H1 receptors. Histamine is a physiologically active, endogenous substance that binds to and activates histamine H1 and H2 receptors in the respiratory tract (including the nose), the gastrointestinal tract, brain, adrenal medulla, skin vasculature, and the heart.

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