Table 56Enteral nutrition -- Economic evaluations: characteristics of studies

Bibliographic referenceComparisonPatient groupIncremental analysisMeasure of effectivenessCost components includedMethod
Beier-Holgersen and Boesby 1996, Denmark271) Nutridrink7
2) Nil-coloured fluid
Patients who had major abdominal surgery (n1=30, n2=30)Cost-effectivenessTotal infectious complicationsHospital costsRCT (30 days follow-up after surgery)
Feo et al 2204, Italy1041) Nasogastric catheter and fasting until passage of flatus feeding
2) Early oral feeding (liquids day 1, soft food day 2)
Patients undergoing elective colorectal resection for cancer (n1=50, n2=50)Cost consequences analysisNo overall measure of effectTotal Hospital costRCT (follow-up to discharge)
Hasse et al 1995, USA1451) Enteral formula8
2) IV fluid
Patients who had liver transplant (n1=14, n2=17)Cost-effectivenessOverall infections in the first 21 days after transplantationHospital costsRCT (21 days follow-up after surgery)
Hedberg et al 19991471) Jejunal feeding tube placed during surgery
2) Usual care
Patients undergoing bowel resections (n1=66, n2=159)Cost-effectivenessPatient developing no postoperative infectionHospital costsProspective non-randomized study (follow-up up to 3 months after discharge)
Mack et al 2004, USA2101) Double-lumen gastrojejunostomy tube
2) Routine care (determined by individual surgeon)
Patients immediately after pancreaticoduodenectomy (n1=20, n2=16)Cost consequences analysisComplications averteda) Total hospital charges
b) Sensitivity analysis: Hospital cost of PN, complications & LOS
RCT (30 days follow-up)
Mitchell et al 2003A, USA2341) Tube-fed
2) Oral feeding by nurse
Nursing home residents aged 65 and over with advanced dementia (n1=11, n2=11)Cost analysisN/ACost of intervention and care9Retrospective study (6 months)
Ofman and Koretz 19972561) Preop ETF
2) No preop ETF
Not specifiedCost analysisAbsolute reduction in post- op complication ratePreop bed days and administration of ETFSensitivity analysis based on two RCTs112,116

Intervention group received Nutridrink through a nasoduodenal feeding tube within four hours postoperatively until the fourth day. Nutridrink contained 150kcal/100 ml and 5g protein/100ml.


Enteral formula was Reabilan HN nasointestinal feeding tubes

From: Appendix Four, Evidence Tables

Cover of Nutrition Support for Adults
Nutrition Support for Adults: Oral Nutrition Support, Enteral Tube Feeding and Parenteral Nutrition.
NICE Clinical Guidelines, No. 32.
National Collaborating Centre for Acute Care (UK).
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