Table 7.57Pain in knee OA

Knee
Pain outcomeReferenceInterventionAssessment timeOutcome/effect size
Number of knees improved (pain)MA (Bellamy et al. 2006a), 1 RCT (N=71)Hydrocortisone tertiary-butylacetate vs placebo2 weeks post-injectionRR 1.81, 95%CI 1.09 to 3.00, p=0.02, NNT=3)
Favours CS
30% decrease in VAS pain from baselineMA (Bellamy et al. 2006a), 1 RCT (N=53)Cortivazol vs placebo vs placebo1 week post-injectionRR 2.56, 95%CI 1.26 to 5.18, p=0.009
Favours CS
15% decrease in VAS pain from baselineMA (Bellamy et al. 2006a), 1 RCT (N=118)Methylprednisolone vs placebo3 weeks post-injectionRR 3.11, 95%CI 1.61 to 6.01, p=0.0007
Favours CS
Pain (VAS)MA (Bellamy et al. 2006a), 3 RCTs (N=161)Cortivazol vs placebo1 week post-injectionWMD −21.91, 95%CI −29.93 to −13.89, p<0.00001
Favours CS
Pain (VAS)MA (Bellamy et al. 2006a), 1 RCT (N=53)Cortivazol vs placebo12 weeks post-injectionWMD −14.20, 95%CI −27.44 to −0.96, p=0.04
Favours CS
WOMAC painMA (Bellamy et al. 2006a), 1 RCT (N=66)Triamcinolone acetonide vs placebo1 year post-injectionWMD −13.80, 95% CI −26.79 to −0.81; p=0.04
Favours CS
Knee
Global assessmentReferenceInterventionAssessment timeOutcome/effect size
Patients global assessment (number of patients preferring treatment)MA (Bellamy et al. 2006a), 3 RCTs (N=190)CS vs placeboRange: 1 to 104 weeksRR 2.22, 95%CI 1.57 to 3.15, p<0.00001
Favours CS
Overall improvementMA (Bellamy et al. 2006a), 3 RCTs (N=156)CS vs placeboRange: 1 to 104 weeksRR 1.44, 95%CI 1.13 to 1.82; p=0.003
Favours CS

From: 7, Pharmacological management of osteoarthritis

Cover of Osteoarthritis
Osteoarthritis: National Clinical Guideline for Care and Management in Adults.
NICE Clinical Guidelines, No. 59.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

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