Table 7.46Symptoms: pain

Pain outcomeReferenceInterventionAssessment timeOutcome/effect size
Knee osteoarthritis
Pain (SDS), mean change after treatment1 RCT (Algozzine et al. 1982) (N=26)Trolamine salicylate vs placebo7 daysNS
Pain (NRS), mean change after treatment1 RCT (Algozzine et al. 1982) (N=26)Trolamine salicylate vs placebo7 daysNS
Hand
Pain intensity (1–5 scale)1 RCT (Rothacker et al. 1998) (N=86)Trolamine salicylate vs placebo45 minutes post-treatment.Right hand: p=0.04
Both hands averaged: p=0.026
Dominant hand: p=0.02
Pain severity (change from baseline1 RCT (Rothacker et al. 1994) (N=50)Trolamine salicylate vs placebo0, 15, 20, 30, 45 and 120 minutes after treatmentNS
Pain intensity (change from baseline)1 RCT (Rothacker et al. 1998) (N=86)Trolamine salicylate vs placeboPooled for 30 minutes, 45 minutes and 120 minutes post-interventionNS
Pain intensity (1–5 scale)1 RCT (Rothacker et al. 1998) (N=86)Trolamine salicylate vs placebo30 minutes and 120 minutes post-interventionNS
Pain intensity (1–5 scale) in the left hand1 RCT (Rothacker et al. 1998) (N=86)Trolamine salicylate vs placebo45 minutes post-intervention.NS
Mixed (knee and/or hip)
Pain at rest, VAS (change from baseline)One RCT (Shackel et al. 1997) (N=116)Copper-salicylate vs placeboEnd of treatment (4 weeks)NS
Pain on movement, VAS (change from baseline)One RCT (Shackel et al. 1997) (N=116)Copper-salicylate vs placeboEnd of treatment (4 weeks)NS

From: 7, Pharmacological management of osteoarthritis

Cover of Osteoarthritis
Osteoarthritis: National Clinical Guideline for Care and Management in Adults.
NICE Clinical Guidelines, No. 59.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

All rights reserved. No part of this publication may be reproduced in any form (including photocopying or storing it in any medium by electronic means and whether or not transiently or incidentally to some other use of this publication) without the written permission of the copyright owner. Applications for the copyright owner’s written permission to reproduce any part of this publication should be addressed to the publisher.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.