Table 7.31Symptoms: stiffness

Stiffness outcomeReferenceInterventionAssessment timeOutcome/effect size
Knee osteoarthritis
WOMAC stiffness1 MA(Towheed 2006) 3 RCTs (N=696)Topical diclofenac vs placeboEnd of treatmentSMD −0.30, 95% CI −0.45 to −0.15, p<0.0001
Favours topical pennsaid
WOMAC stiffness1 MA(Towheed 2006) 1 RCT (N=622)Topical diclofenac vs oral diclofenacEnd of treatmentNS
Knee or hand or mixed sites
Stiffness reduction (from baseline)1 MA (Lin et al. 2004) Week 1: 1 RCT (N=74)Topical NSAIDs vs placeboWeek 1Week 1: effect size 0.64, 95% CI 0.19 to 1.09, p≤0.05
Favours topical NSAIDs
Stiffness reduction (from baseline)1 MA (Lin et al. 2004) Week 2: 1 RCT (N=81)Topical NSAIDs vs placeboWeek 24NS

From: 7, Pharmacological management of osteoarthritis

Cover of Osteoarthritis
Osteoarthritis: National Clinical Guideline for Care and Management in Adults.
NICE Clinical Guidelines, No. 59.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

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