Table 6.80Symptoms: function

Function outcomeReferenceInterventionAssessment timeOutcome/effect size
Knee
Glucosamine hydrochloride
WOMAC function score, change from baseline; HAQ disability score, change from baseline; joint swelling, effusion or both on clinical examination1 RCT (Clegg et al. 2006) (N=1583)GH vs placebo24 weeks (end of treatment)NS
Glucosamine sulphate
Lequesne’s Index (change from baseline)1 RCT (Herrero-Beaumont et al. 2007) (N=325)GS vs placebo6 months (end of treatment)Mean difference −1.2,% CI −2.3 to −0.8, p=0.032
Favours GS
WOMAC total (change from baseline)1 RCT (Herrero-Beaumont et al. 2007) (N=325)GS vs placebo6 months (end of treatment)Mean difference −4.7,% CI −9.1 to −0.2, p=0.039
Favours GS
WOMAC physical function (change from baseline)1 RCT (Herrero-Beaumont et al. 2007) (N=325)GS vs placebo6 months (end of treatment)Mean difference −3.7,% CI −6.9 to −0.5, p=0.022
Favours GS
Mixed (knee or mixed or unspecified sites)
Glucosamine (general)
Lequesne Index1 MA (Towheed et al. 2005) 2 RCTs, N=407Glucosamine vs placeboTrial length: range 3 weeks to 3 years; follow-up: range immediate to 8 weeksRR 1.52,% CI 1.20 to 1.91, p=0.0005
Favours glucosamine
Lequesne Index, relative risk1 MA (Towheed et al. 2005) 4 RCTs, N=741Glucosamine vs placeboTrial length: range 3 weeks to 3 years; follow-up: range immediate to 8 weeksNS
WOMAC function1 MA (Towheed et al. 2005) 6 RCTs, N=750Glucosamine vs placeboTrial length: range 3 weeks to 3 years; follow-up: range immediate to 8 weeksNS
WOMAC total1 MA (Towheed et al. 2005) 5 RCTs, N=672Glucosamine vs placeboTrial length: range 3 weeks to 3 years; follow-up: range immediate to 8 weeksNS

From: 6, Non-pharmacological management of osteoarthritis

Cover of Osteoarthritis
Osteoarthritis: National Clinical Guideline for Care and Management in Adults.
NICE Clinical Guidelines, No. 59.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

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