Table 6.27Study withdrawals

Withdrawals outcomeReferenceInterventionAssessment timeOutcome/effect size
Knee osteoarthritis
Manual therapy vs sham ultrasound
Number of withdrawals1 RCT (Bennell et al. 2005), N=140Manual therapy (knee taping, mobilisation, massage) + exercise vs control (sham ultrasound)12 weeks (end of treatment) and 12 weeks post-treatment12 weeks: 18% (manual) and 3% (control)
12 weeks post-treatment: 23% (manual) and 6% (control)
Control better
Number of withdrawals1 RCT (Deyle et al. 2000), N=83Manual therapy (movements, mobilisation and stretching) + exercise vs control (sham ultrasound)4 weeks (end of treatment)12% (manual) and 21% (control)
Manual better
Manual therapy vs exercise
Number of withdrawals + number lost to follow-up1 RCT (Hoeksma et al. 2004), N=109Manual therapy (manipulation + stretching) vs exerciseEnd of study (week 5) and 6 months (5 months post-intervention)N=15 (manual) and N=13 (exercise)
Both groups similar
Withdrawals due to AEs, increase of complaints1 RCT (Hoeksma et al. 2004), N=109Manual therapy (manipulation + stretching) vs exerciseEnd of study (week 5)N=3 (manual) and N=2 (exercise)
Both groups similar

From: 6, Non-pharmacological management of osteoarthritis

Cover of Osteoarthritis
Osteoarthritis: National Clinical Guideline for Care and Management in Adults.
NICE Clinical Guidelines, No. 59.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

All rights reserved. No part of this publication may be reproduced in any form (including photocopying or storing it in any medium by electronic means and whether or not transiently or incidentally to some other use of this publication) without the written permission of the copyright owner. Applications for the copyright owner’s written permission to reproduce any part of this publication should be addressed to the publisher.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.