Table 11Relative Risk of GI adverse events when add a PPI, compared to no PPI

Adverse eventAdded to a standard NSAIDAdded to a Cox-2
GI symptoms0.43 (0.24–0.76)0.25 (0.03–0.78)
Symptomatic ulcer0.37 (0.30–0.46)0.25 (0.03–0.78)
Complicated GI bleed0.46 (0.07–2.92)0.25 (0.03–0.78)

Figures in brackets represent 95% confidence intervals

From: Appendix D, Details of the NSAID/COX-2 inhibitor health economic model

Cover of Osteoarthritis
Osteoarthritis: National Clinical Guideline for Care and Management in Adults.
NICE Clinical Guidelines, No. 59.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2008, Royal College of Physicians of London.

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