Table 7.9Amantadine compared with placebo at different time points239

After 15 and 30 days’ treatmentAfter 8 months’ treatmentAfter 1 month withdrawal
Clinical rating scale
UPDRS items 32–34 (self-assessment)ANS-BNS
Motor complications
IGA scores of dyskinesiaNS-ANS-BNS
DRS total scoresNS-ANS-BNS

A = favours amantadine (p<0.05); NS-A = non-significant improvement in amantadine; NS = no differences between groups; NS-B = non-significant worsening in amantadine; IGA = Investigator Global Assessment; DRS = Dyskinesia Rating Scale.

From: 7, Symptomatic pharmacological therapy in Parkinson’s disease

Cover of Parkinson's Disease
Parkinson's Disease: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care.
NICE Clinical Guidelines, No. 35.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2006, Royal College of Physicians of London.

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