Table 7.4Options for adjuvant pharmacotherapy in later PD

Adjuvant therapy for later PDFirst-choice optionSymptom controlPossible risk of side effects
Motor complicationsOther adverse events
Dopamine agonists++
COMT inhibitors++
MAOB inhibitors++

Good degree of symptom control.


Moderate degree of symptom control.


Limited degree of symptom control.

Evidence of increased motor complications/other adverse events.

Evidence of reduced motor complications/other adverse events.

NS = Non-significant result.

From: 7, Symptomatic pharmacological therapy in Parkinson’s disease

Cover of Parkinson's Disease
Parkinson's Disease: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care.
NICE Clinical Guidelines, No. 35.
National Collaborating Centre for Chronic Conditions (UK).
Copyright © 2006, Royal College of Physicians of London.

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