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Helfand M, Peterson K. Drug Class Review: Triptans: Final Report Update 4 [Internet]. Portland (OR): Oregon Health & Science University; 2009 Jun.

Appendix D. Excluded studies

StudyReason for exclusion
Adelman JU, Mannix LK and Von Seggern RL. Rizatriptan tablet versus wafer: Patient preference. Headache. 2000;40(5):371–372.Wrong Drug or Comparison
Anonymous. Investigational 'triptan' improves 2-hour headache response compared with oral sumatriptan. Formulary. 1999;34(10):819–820.Wrong Drug or Comparison
Ashford E, Salonen R, Saiers J, et al. Consistency of response to sumatriptan nasal spray across patient subgroups and migraine types. Cephalalgia. 1998;18(5):273–277.Wrong Outcome
Bahra A, Gawel MJ, Hardebo JE, et al. Oral zolmitriptan is effective in the acute treatment of cluster headache. Neurology. 2000;54(9):1832–1839.Wrong Population
Burke-Ramirez P, Webster C, Laurenza A, et al. Efficacy of sumatriptan injection for the acute treatment of migraine in a primarily non-caucasian group of patients. Functional Neurology. 1998;2(13):182.Wrong Publication Type-ABSTRACT ONLY
Cabanas A and Rodriguez RRFCA. Subcutaneous sumatriptan comparative study versus placebo in migraine attacks. Journal of the Neurological Sciences. 1997;150(Suppl):S303.Wrong Publication Type-ABSTRACT ONLY
Cabarrocas X and Almotriptan Study G. Efficacy and tolerability of subcutaneous almotriptan for the treatment of acute migraine: a randomized, double-blind, parallel-group, dose-finding study. Clinical Therapeutics. 2001;23(11):1867–75.Wrong Drug or Comparison
Cabarrocas X, Zayas JM and Suris M. Equivalent efficacy of oral almotriptan, a new 5-HT1B/1D agonist, compared with sumatriptan 100mg. 40th Annual Scientific Meeting of the American Association for the Study of Headache. 1998.Wrong Publication Type-ABSTRACT ONLY
Cady R, Martin V, Adelman J, et al. Migraine treatment with rizatriptan and non- triptan usual care medications: a pharmacy-based study. Headache. Oct 2004;44(9):900–7.Wrong Outcome
Cady RC, Ryan R, Jhingran P, et al. Sumatriptan injection reduces productivity loss during a migraine attack: results of a double-blind, placebo-controlled trial. Neurology. 1997;48(3):A121.Wrong Publication Type
Cittadini E, May A, Straube A, et al. Effectiveness of intranasal zolmitriptan in acute cluster headache: a randomized, placebo-controlled, double-blind crossover study. Archives of Neurology. Nov 2006;63(11):1537–42.Wrong Population
Cutler NR, Claghorn J, Sramek JJ, et al. Pilot study of MK-462 in migraine. Cephalalgia. 1996;16(2):113–116.Wrong Drug or Comparison
Dahlof CG, Lipton RB, McCarroll KA, et al. Within-patient consistency of response of rizatriptan for treating migraine. Neurology. 2000;55(10):1511–6.Wrong Design
Di Monda V, Nicolodi M, Aloisio A, et al. Efficacy of a fixed combination of indomethacin, prochlorperazine, and caffeine versus sumatriptan in acute treatment of multiple migraine attacks: a multicenter, randomized, crossover trial. Headache. 2003;43(8):835–44.Wrong Drug or Comparison
Diener HC, Pascual J and Vega P. Comparison of rizatriptan 10mg versus zolmitriptan 2.5mg in migraine. Headache. 1999;39:351.Wrong Publication Type-ABSTRACT ONLY
Disability in Strategies of Care Study g. Stratified care vs step care strategies for migraine: the Disability in Strategies of Care (DISC) Study: A randomized trial. JAMA : the journal of the American Medical Association. 2000;284(20):2599–605.Wrong Design
Dowson A. Can oral 311C90, a novel 5-HT(1D) agonist, prevent migraine headache when taken during an aura? European Neurology. 1996;36(SUPPL. 2):28–31.Wrong Outcome
Dowson AJ, Charlesworth BR, Purdy A, et al. Tolerability and consistency of effect of zolmitriptan nasal spray in a long-term migraine treatment trial. Cns Drugs. 2003;17(11):839–51.Wrong Design
Eletriptan Steering C. Efficacy, safety, and tolerability of oral eletriptan for treatment of acute migraine: a multicenter, double-blind, placebo-controlled study conducted in the United States. Headache. 2003;43(3):202–13.Wrong Outcome
Elkind AH, Satin LZ, Nila A, et al. Frovatriptan use in migraineurs with or at high risk of coronary artery disease. Headache. 2004;44(5):403–10.Wrong Outcome
Encarnacion JR, Ellis MR and Lindbloom EJ. Is oral zolmitriptan efficacious in the acute treatment of cluster headache? Journal of Family Practice. 2000;49(9):784, 849.Wrong Population
Fernandez FJ, Cabarrocas X, Zayas JM, et al. Oral almotriptan in the treatment of migraine: a dose finding study. Cephalalgia. 1999;19:362.Wrong Publication Type-ABSTRACT ONLY
Ferrari MD. Treatment of migraine attacks with sumatriptan. New England Journal of Medicine. 1991;325(5):316–321.Wrong Outcome
Fleishaker JC, McEnroe JD, Azie NE, et al. Cardiovascular effect of almotriptan in treated hypertensive patients. Clinical Pharmacology & Therapeutics. 2002;71(3):169–75.Wrong Outcome
Gallagher RM. Comparison of zolmitriptan and sumatriptan for the acute treatment of migraine. Cephalalgia. 1999;19:358.Wrong Publication Type-ABSTRACT ONLY
Goadsby PJ, Zagami AS, Donnan GA, et al. Oral sumatriptan in acute migraine. Lancet. 1991;338(8770):782–3.Wrong Outcome
Goldstein DJ, Roon KI, Offen WW, et al. Selective seratonin 1F (5-HT(1F)) receptor agonist LY334370 for acute migraine: a randomised controlled trial. Lancet. 2001;358(9289):1230–4.Wrong Drug or Comparison
Goldstein J, Keywood C and Hutchison J. 24-hour migraine recurrence was low during treatment with frovatriptan. European Journal of Neurology. 1999;6(Supplement 3).Wrong Publication Type-ABSTRACT ONLY
Hardebo JE and Dahlof C. Sumatriptan nasal spray (20 mg/dose) in the acute treatment of cluster headache. Cephalalgia. 1998;18(7):487–489.Wrong Drug or Comparison
Hutchinson J, Pfaffenrath V and Geraud G. A randomized, placebo-controlled, parallel-group trial of frovatriptan and sumatriptan for a single acute migraine attack [abstract]. European Journal of Neurology. 2007;14(suppl 1)(144):P1458.Wrong Publication Type
Katsarava Z, Fritsche G, Muessig M, et al. Clinical features of withdrawal headache following overuse of triptans and other headache drugs. Neurology. 2001;57(9):1694–8.Wrong Outcome
Kozma CM and Reeder CE. Comparison of the economic, clinical, and humanistic attributes of dihydroergotamine and sumatriptan. Clinical Therapeutics. 1995;17(2):315–319.Wrong Drug or Comparison
Lipton RB, Stewart WF, Cady R, et al. 2000 Wolfe Award. Sumatriptan for the range of headaches in migraine sufferers: results of the Spectrum Study. Headache. 2000;40(10):783–91.Wrong Population
Loder E, Brandes JL, Silberstein S, et al. Preference comparison of rizatriptan ODT 10-mg and sumatriptan 50-mg tablet in migraine. Headache. 2001;41(8):745–53.Wrong Drug or Comparison
Massiou and H. A comparison os sumatriptan nasal spray and intranasal dhiydroergotamine (DHE) in the acute treatment of migraine. Functional Neurology. 1996;2/3(11):151.Wrong Publication Type-ABSTRACT ONLY
Mathew NT, Kailasam J, Gentry P, et al. Treatment of nonresponders to oral sumatriptan with zolmitriptan and rizatriptan: a comparative open trial. Headache. 2000;40(6):464–5.Wrong Publication Type-ABSTRACT ONLY
Milton KA, Scott NR, Allen MJ, et al. Pharmacokinetics, pharmacodynamics, and safety of the 5-HT(1B/1D) agonist eletriptan following intravenous and oral administration. Journal of Clinical Pharmacology. 2002;42(5):528–39.Wrong Population
O’Quinn S and Salonen R. Sumatriptan nasal spray compared with intranasal dihydroergotamine in the acute treatment of migraine: results of a comparator trial. Headache. 1998;38:396.Wrong Publication Type-ABSTRACT ONLY
Oral Sumatriptan International Multiple-Dose Study G. Evaluation of a multiple- dose regimen of oral sumatriptan for the acute treatment of migraine. European Neurology. 1991;31(5):306–13.Wrong Design
Pascual J, Bussone G, Hernandez JF, et al. Comparison of preference for rizatriptan 10-mg wafer versus sumatriptan 50-mg tablet in migraine. European Neurology. 2001;45(4):275–283.Wrong Drug or Comparison
Pradel FG, Subedi P, Varghese AA, et al. Does earlier headache response equate to earlier return to functioning in patients suffering from migraine? Cephalalgia. Apr 2006;26(4):428–35.Wrong Drug or Comparison
Pryse-Phillips W. Oral eletriptan (40–80 mg) versus oral sumatriptan (50–100 mg) for the treatment of acute migraine in sumatriptanna[spacing acute]ve patients. European Journal of Neurology. 1999;6(Supplement 3):7–11.Wrong Publication Type-ABSTRACT ONLY
Pryse-Phillips W and Committee ES. Comparison of oral eletriptan (40–80mg) and oral sumatriptan (50–100mg) for the treatment of acute migraine: a randomised, placebo-controlled trial in sumatriptan-naive patients. Cephalalgia. 1999;19:355.Wrong Publication Type-ABSTRACT ONLY
Reches A. Comparison of the efficacy, safety and tolerability of oral eletriptan and cafergot(r) in the acute treatment of migraine. European Journal of Neurology. 1999;6(Supplement 3):7–11.Wrong Design
Robbins L. Triptans versus analgesics. Headache. 2002;42(9):903–7.Wrong Design
Robert M, Cabarrocas X, Fernandez FJ, et al. Efficacy and tolerabilty of oral almotriptan in the treatment of migraine. Cephalalgia. 1998;18:406.Wrong Publication Type-ABSTRACT ONLY
Russell MB, Holm TOE, Nielsen MR, et al. Subcutaneous sumatriptan in general practice: A randomized double- blind placebo-controlled cross-over study. Ugeskrift for Laeger. 1995;157(16):2320–2323.Non-English Language
Saiers J, Jones M, Kane K, et al. Naratriptan tablets 2.5 Mg exhibit prolonged action and are well-tolerated in non-severe migraine attacks: data from a comparator study with sumatriptan. European Journal of Neurology. 1999;6(Supplement 3).Wrong Publication Type-ABSTRACT ONLY
Sakai F. Safety and tolerability of rizatriptan. Cephalalgia, Supplement. 2000;20(1):16–18.Wrong Outcome
Salonen R, Petricoul O, Sabin A, et al. Encapsulation delays absorption of sumatriptan tablets. Cephalalgia. 2000;20:423–4.Wrong Outcome
Savani N, Pfaffenrath V, Rice L, et al. Efficacy, tolerability, and patient satisfaction with 50- and 100-mg sumatriptan tablets in those initially dissatisfied with the efficacy of 50-mg sumatriptan tablets. Clinical Therapeutics. 2001;23(2):260–71.Wrong Design
Schoenen J, Jones M, Kane K, et al. Naratriptan 2.5mg tablets have similar efficacy in the acute treatment of migraine as zolmitriptan 2.5mg tablets, but exhibit a longer duration of action and are better tolerated: results of a comparator study [abstract]. Neurology. 1999;52(6 Suppl 2):A257–258.Wrong Publication Type
Schoenen J, Pascual J, Rasmussen S, et al. Patient preference for eletriptan 80 mg versus subcutaneous sumatriptan 6 mg: results of a crossover study in patients who have recently used subcutaneous sumatriptan. European Journal of Neurology. Feb 2005;12(2):108–17.Wrong Drug or Comparison
Silberstein SD. Rizatriptan versus usual care in long-term treatment of migraine. Neurology. 2000;55(9 SUPPL. 2):S25–S28.Wrong Design
Steiner TJ and Eletriptan Steering Committee. Efficacy, safety and tolerability of oral eletriptan (40mg and 80mg) in the acute treatment of migraine: results of a phase III study. Cephalalgia. 1999;18:385.Wrong Publication Type-ABSTRACT ONLY
Tfelt-Hansen P and Steiner TJ. Sumatriptin vs dihydroergotamine: Patient preference [1]. International Journal of Clinical Practice. 2001;55(2):151.Wrong Design
The S2MB11 Study Group. Patients preference between 25, 50 and 100mg oral doses of sumatriptan. European Journal of Neurology. 1996;3(1):86.Wrong Publication Type-ABSTRACT ONLY
Visser WH and Jiang K. Effect of rizatriptan versus sumatriptan on migraine- associated symptoms. Headache. 1998:409.Wrong Publication Type
Wilding I, Clark D, Wray H, et al. Disintegration Profiles of Encapsulated And Non-Encapusulated Sumatriptan: Gamma Scientography in Healthy Volunteers. Journal of Clinical Pharmacology. 2005;45.Wrong Outcome- Included for Background
Copyright © 2009, Oregon Health & Science University, Portland, Oregon.
Cover of Drug Class Review: Triptans
Drug Class Review: Triptans: Final Report Update 4 [Internet].
Helfand M, Peterson K.
Portland (OR): Oregon Health & Science University; 2009 Jun.


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