Table 9

Main results in placebo-controlled trials in children with seasonal allergic rhinitis

Study
Sample size
NCS (total daily dose) x duration (weeks)Main results
Kobayashi, 1989
N=101
Beclomethasone
168 mcg x 3
Significant decline in nasal obstruction, rhinorrhea, sneezing, and nasal itch as rated by physicians and patients (data NR)
Strem, 1978
N=48
Flunisolide
150 mcg x 4
All symptoms combined absent or questionably noted (# days): 5.6 compared with 1.2; P<0.0001
Patient felt spray achieved ‘total control’ (% pts): 16.7% compared with 4.2%; P=0.0011
Gale, 1980
N=35
Flunisolide
200 mcg x 4
Substantial or total control (% pts): 64% compared with 33%; P<0.05
Individual symptom relief: sneezing=NS; stuffy nose P<0.05; runny nose P<0.05; eye itch=NS
Boner, 1995
N=143
Fluticasone
100 or 200 mcg QD x 4
Percentage of symptom-free days:
Sneezing=55% compared with 42% compared with 22%; P<0.05
Rhinorrhea=70% compared with 59% compared with 30%; P<0.05
Galant, 1994
N=249
Fluticasone
100 or 200 mcg QD x 4
‘Significant improvement’ (% pts; clinician-rated): 29% compared with 35% compared with 11%; P<0.01
‘Magnitude’ of improvement (% reduction in pt-rated mean total nasal symptom scores): 50–57% compared with 37%; P<0.05
Grossman, 1993
N=250
Fluticasone
100 or 200 mcg QD x 2
‘Significant improvement’ (% pts; clinician-rated): 29% compared with 21% compared with 9%; P<0.002
Munk, 1994
N=243
Fluticasone 100 or 200
mcg QD x 2
‘Significant improvement’ (% pts; clinician-rated): 33% compared with 32% compared with 9%; P<0.001
Schenkel, 1997
N=223
Triamcinolone
110 or 220 mcg x 2
Adjusted mean change from baseline in Nasal Index:
−2.62 compared with −2.50 compared with −1.78; P<0.05
Banov, 1996
N=116
Triamcinolone
220 mcg QD x 2
Adjusted mean change from baseline in Nasal Index:
−2.30 compared with −1.16; P<0.05

From: Results

Cover of Drug Class Review: Nasal Corticosteroids
Drug Class Review: Nasal Corticosteroids: Final Report Update 1 [Internet].
Selover D, Dana T, Smith C, et al.
Portland (OR): Oregon Health & Science University; 2008 Jun.
Copyright © 2008, Oregon Health & Science University, Portland, Oregon.

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