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Drug Class Review: Beta Adrenergic Blockers: Final Report Update 4 [Internet]

Drug Class Review: Beta Adrenergic Blockers: Final Report Update 4 [Internet]

Drug Class Reviews - Oregon Health & Science University

Version: July 2009

Introduction

Beta blockers inhibit the chronotropic, inotropic, and vasoconstrictor responses to the catecholamines, epinephrine, and norepinephrine. Most beta blockers have half-lives of over 6 hours (Table 1). The shortest acting are pindolol (3 to 4 hours) and propranolol (3 to 5 hours). Most of the included beta blockers are metabolized in combination by the liver and kidneys, with the exception of atenolol, which is metabolized primarily by the kidneys while the liver has little to no involvement.

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