Table 7Omega-3 fatty acids and risk of developing AD – recent cohort studies

StudySample size (n)Followup/EventsExposureCase definitionConfounding adjustmentResults
Devore et al., 200980Community cohort (5395)Mean 9.6 years

365 AD of total 465 incident dementia
Total and fatty fish intake at baseline
PUFAs at baseline by food frequency questionnaire
Total energy intake
Total cholesterol
Dietary vitamin E
Supplement use
Vascular risk factors
AD risk for high vs. no fish intake: HR 0.99 (95% CI 0.76 to 1.29)
No association for long chain omega-3, EPA, or DHA intake
Kroger et al., 200981Community cohort (663)Median 4.9 years

105 AD of total 149 incident dementia
Blood total and erythrocyte membrane PUFAs at baselineNINCDS-ADRDAAge
Vascular risk factors
History of depression
Family history of dementia
No association for dementia or AD with total PUFA, EPA, or DHA

AD risk for highest quartile of total PUFA: HR 1.12 (95% CI 0.63 to 1.98)

Abbreviations: AD = Alzheimer’s disease; BMI = body mass index; CI = confidence interval; DHA = docosahexaenoic acid; EPA = eicosapentaenoic acid; HR = hazard ratio; NINCDS-ADRDA = National Institute of Neurological and Communicative Diseases and Stroke-Alzheimer's Disease and Related Disorders Association; PUFA(s) = polyunsaturated fatty acid(s); RR = relative risk

From: 3, Results

Cover of Preventing Alzheimer's Disease and Cognitive Decline
Preventing Alzheimer's Disease and Cognitive Decline.
Evidence Reports/Technology Assessments, No. 193.
Williams JW, Plassman BL, Burke J, et al.

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