5.2.2Assessing ovulation: prolactin

StudyPopulationInterventionOutcomesResultsCommentsStudy typeEL
Vanrell 1983315130 infertile but ovulatory women and no galactorrhea undergoing evaluation of luteal functionSerum prolactin measurementRaised serum prolactin: 15/130 (11.5%); 1/15 (6.6%) with inadequate luteal phase

Normal serum prolactin: 115/130 (88.5%); 20/115 (17.4%) with inadequate luteal phase
Laufer et al. 199531698 ovulatory women aged 25–43 years with tubal infertility undergoing IVFSerum prolactin versus reference lab normal valuesSerum prolactin measurementSignificantly higher level: 7/98 (7.1%, CI 2.9% to 14%)Other outcomes measured: TSH

Analysis also stratified by age
Varkopoulou et al. 1993317292 patients from infertility clinicSerum prolactin levelsSerum prolactin > 600 miu: 33/292 (11.3%)

Hyperprolactinaemia: 11/292 (3.8%)
Glazener et al. 1987318188 infertile women aged 18–41 years with normal menstrual cycle, thyroid-stimulating hormone and FSHSerum prolactin levels

Progesterone and cumulative conception rates
No significant association

Serum prolactin levels range: < 200 miu/l to > 800 miu/l
12 months follow-upOB3
Stratford et al. 1999319315 infertile womenSerum prolactin levels

Prevalence of raised serum prolactin (> 500 miu)
Serum prolactin levels range: 77 to 1629 miu/l

2/315 (0.63%) with menstrual dysfunction

20/315 (6.3%) with serum prolactin of 500–800 miu ovulatory
Normal ovulation occurs when PRL < 800 miuOB3

From: Evidence tables

Cover of Fertility
Fertility: Assessment and Treatment for People with Fertility Problems.
NICE Clinical Guidelines, No. 11.
National Collaborating Centre for Women's and Children's Health (UK).
London (UK): RCOG Press; 2004 Feb.
Copyright © 2004, National Collaborating Centre for Women’s and Children’s Health.

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