Table 6Prevalence of hypolactasia

StudyNumber Subject Selection Inclusion/ExclusionSubject CharacteristicsDiagnostic MethodsPrevalence of Hypolactasia
Asymptomatic at baseline
Newcomer, 196718
US
N=100
Subject selection: Healthy Caucasians
Exclusion: Intolerance to milk and/or GI symptoms
Mean age: 38.5 (20–63)
  Males mean age: 37 (20–63)
 Females mean age: 40 (21–62)
Males: n=50
Females: n=50

Race/ethnicity: Caucasians
BiopsyOverall (≤0.5 U): 6% (95% CI 1.3%–10.3%)
Asymptomatic and symptomatic at baseline
Ferguson,198450
UK
N=406
Subject selection:
1) retrospective evaluation of White, adult subjects who had had a jejunal biopsy performed (n=150)
2) non White British (n=20)
3) investigated because of diarrhea after gastric surgery (n=36)
4) subjects with irritable bowel syndrome (n=200)

Inclusion/exclusion: For the 150 White British sample only those that had no significant intestinal disease; all had normal histopathic jejunal biopsy
Mean age: NA
Males: NA
Females: NA

Race/ethnicity: “White” British, and non White British (Indian, Chinese, Black, Arab)
BiopsyGroups: White British adults without GI disease: 7/150 (4.7%)
Non White British: 15/20 (75%)
Diarrhea after gastric surgery: 3/36 (8%)
IBS group: 16/200 (8%)
Lebenthal, 198151
USA
N=156
Subject selection: in a case-controlled study, White children (n=95) with recurrent abdominal pain, plus 61 age-and race-matched Controls who had undergone diagnostic intestinal biopsies primarily for chronic diarrhea

Inclusion: diagnosis of recurrent abdominal pain
Mean age: NA (6–14)
Males: NA
Females: NA

Race/ethnicity: White
BiopsyOverall: 24/87 (27.6%)
Subgroups
White children: 8/26 (31%)
Controls: 16/61 (26.4%)
Welsh, 197053
USA
N=250
Sample: Intestinal specimens from patients without celiac sprue.

Inclusion/exclusion: NA
Mean age: NA (2–81)
Males: n=169
Females: n=81

Race/ethnicity
White: n=209
Black: n=39
American Indian: n=2
BiopsyOverall (duodenojejunal): 85/250 (34%)
Overall (isolated lactase deficiency (Billroth II procedures)): 9/250 (3.6%)
Symptomatic at baseline
Pfefferkorn 200252
US
N=224 (patients with IBD n=112, patients with chronic abdominal pain n=112)
Sample: retrospective and descriptive analysis of pediatric and adolescent patients with IBS were compared to a random sample of age-and gender-matched controls who were being evaluated for abdominal pain

Inclusion/exclusion:
Mean age (IBS): 12.7
Mean age (controls): 12.4 (1.9–18.7)
Males: n=60
Females: n=52

Race/ethnicity
White: n=103
Black: n=9
BiopsyOverall: NA

Subgroups
IBS: 45/112 (40%)
Chronic abdominal pain: 34/112 (30%)
P=0.16

Among 112 with IBD
Whites: 38/103 (37%)
African Americans: 7/9 (78%)

From: 3, Results

Cover of Lactose Intolerance and Health
Lactose Intolerance and Health.
Evidence Reports/Technology Assessments, No. 192.
Wilt TJ, Shaukat A, Shamliyan T, et al.

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