Evidence Table 14FVL predicting events in family members, study characteristics

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Reference List
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  2. Middeldorp S, Henkens CM, Koopman MM et al. The incidence of venous thromboembolism in family members of patients with factor V Leiden mutation and venous thrombosis. Ann Intern Med 1998; 128(1):15–20.
  3. Le Cam-Duchez V, Gandrille S, Tregouet D et al. Influence of three potential genetic risk factors for thrombosis in 43 families carrying the factor V Arg 506 to Gln mutation. Br J Haematol 1999; 106(4):889–97.
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  5. Simioni P, Prandoni P, Girolami A. Low rate of venous thromboembolism in asymptomatic relatives of probands with factor V Leiden mutation. Ann Intern Med 1999; 130(6):538.
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  7. Martinelli I, Bucciarelli P, Margaglione M, De Stefano V, Castaman G, Mannucci PM. The risk of venous thromboembolism in family members with mutations in the genes of factor V or prothrombin or both. Br J Haematol 2000; 111(4):1223–9.
  8. Simioni P, Tormene D, Luni S, Caldato M, Girolami A. Clinical and laboratory expression of associated thrombophilic conditions (homozygous/heterozygous factor V Leiden mutation and heterozygous prothrombin variant 20210A) in an Italian family. Blood Coagul Fibrinolysis 2000; 11(4):379–84.
  9. Lensen R, Bertina RM, Vandenbroucke JP, Rosendaal FR. High factor VIII levels contribute to the thrombotic risk in families with factor V Leiden. Br J Haematol 2001; 114(2):380–6.
  10. Middeldorp S, Meinardi JR, Koopman MM et al. A prospective study of asymptomatic carriers of the factor V Leiden mutation to determine the incidence of venous thromboembolism. Ann Intern Med 2001; 135(5):322–7.
  11. Rintelen C, Pabinger I, Bettelheim P et al. Impact of the factor II: G20210A variant on the risk of venous thromboembolism in relatives from families with the factor V: R506Q mutation. Eur J Haematol 2001; 67(3):165–9.
  12. Meinardi JR, Middeldorp S, de Kam PJ et al. The incidence of recurrent venous thromboembolism in carriers of factor V Leiden is related to concomitant thrombophilic disorders. Br J Haematol 2002; 116(3):625–31.
  13. Simioni P, Tormene D, Prandoni P et al. Incidence of venous thromboembolism in asymptomatic family members who are carriers of factor V Leiden: a prospective cohort study. Blood 2002; 99(6):1938–42.
  14. Vossen CY, Conard J, Fontcuberta J et al. Familial thrombophilia and lifetime risk of venous thrombosis. J Thromb Haemost 2004; 2(9):1526–32.
  15. Vossen CY, Conard J, Fontcuberta J et al. Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). J Thromb Haemost 2005; 3(3):459–64.
  16. Couturaud F, Kearon C, Leroyer C et al. Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden. Thromb Haemost 2006; 96(6):744–9.
    Notes: CORPORATE NAME: Groupe d’Etude de la Thrombose de Bretagne Occidentale (G.E.T.B.O)

From: Appendix G, Evidence Tables

Cover of Outcomes of Genetic Testing in Adults with a History of Venous Thromboembolism
Outcomes of Genetic Testing in Adults with a History of Venous Thromboembolism.
Evidence Reports/Technology Assessments, No. 180.
Segal JB, Brotman DJ, Emadi A, et al.

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