Author, yearStudy DesignRandom assignment?Allocation concealed?Groups similar at baseline?Eligibility criteria specified?Blinding: outcome assessors, care provider, patient?Intention-to-treat analysis?Maintenance of comparable groups?Reporting of attrition, contamination, etc.?Differential loss to follow-up or overall high loss to follow-up?Quality ratingExternal validity
Bowen et al, 200438 RCTYesYesYesYesN/ANRYesYes1% loss genetic counselingFairWomen in general public with breast cancer
4% loss psychosocial counseling
1% loss control
Bowen et al, 200239 RCTYesNRYesYesN/ANoYesYes8% loss psychosocial counselingFairWomen in Seattle area with lower risk of breast cancer
10% loss genetic counseling
10% loss control
Burke et al, 200040 RCTYesNRYesYesN/ANRYesYes3% loss counselingFairWomen in Seattle area with intermediate family history of breast cancer
8% loss control
Cull et al, 199841 RCTYesYesYesYesN/ANRYesYes24% loss videoGoodWomen from 4 Scottish cancer family clinics
37% loss control
Green et al, 2004120 RCTYesN/AYesYesN/ANRYesYes26% loss overall at 6 month follow-upGoodWomen from 6 U.S. medical center clinics offering genetic counseling
Lerman et al, 199942 RCTYesNRYesYesN/ANRNoYes49% loss overallFairGeorgetown University Medical Center and Washington Hospital Center
(32% loss Causasian; 51% loss African American)
Lerman et al, 199643 RCTYesNRYesYesOutcome assessors blind onlyNRYesYes12% loss overall 3-month telephone surveyFairCancer treatment centers
37% loss overall 3-month mail survey
Lerman et al, 199544 RCTYesNRYesYesOutcome assessors blind onlyNoYesYes12% loss overallFairFox Chase Cancer Center and Duke Comprehensive Cancer Center
Lobb et al, 2002118 RCTYesYesYesYesN/AYesYesYes18% loss overallGood10 familial cancer clinics in 4 Australian states
Watson et al, 1998119 RCTYesYesYesYesN/AYesYesYes7% loss overall 1-month follow-upGoodWomen with a family history of breast cancer attending two London genetic clinics
21% loss overall 6-month follow-up

NR, not reported; RCT, randomized controlled trial.

From: Appendix H. Quality Ratings of Genetic Counseling Studies

Cover of Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility
Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility [Internet].
Evidence Syntheses, No. 37.
Nelson HD, Huffman LH, Fu R, et al.

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