Table 3Randomized controlled trials comparing major primary treatment options and reporting any clinical outcome

Radical ProstatectomyWatchful WaitingExternal Beam RadiotherapyAdjuvant or Neoadjuvant TherapyBrachytherapy
Radical ProstatectomyOS; DSS; DM; AE; QoLbNED; DMOS; DSS; bNED; DM; AE
Watchful WaitingOS; DSS; DM; AE; QoL
External Beam RadiotherapybNED; DMOS; DSS; bNED; DM; AEOS; DSS; bNED; AE
Adjuvant or Neoadjuvant Androgen Deprivation TherapyOS; DSS; bNED; DM; AEOS; DSS; bNED; AEbNED
BrachytherapybNEDbNED; AE

Note: Neither androgen deprivation therapy nor cryotherapy were tested in randomized controlled trials.

OS = Overall survival

DSS = Disease-specific survival

bNED = Biochemical no evidence of disease

DM = Distant metastasis

AE = Adverse effects/toxicity

QoL = Quality of life

From: 3, Results

Cover of Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer
Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer [Internet].
Comparative Effectiveness Reviews, No. 13.
Wilt TJ, Shamliyan T, Taylor B, et al.

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