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Effectiveness of Assisted Reproductive Technology

Effectiveness of Assisted Reproductive Technology

Evidence Reports/Technology Assessments - Agency for Healthcare Research and Quality (US)

Version: May 2008


Despite screening 181 full-text articles for eligibility, we are limited in our ability to draw conclusions about most of the topics discussed under Question 2. Several methodologic issues were consistently seen in our review.


Among women of reproductive age, what are the benefits and risks of Clomid® and Pergonal® (or other injectable super-ovulatory drugs) and Glucophage®, and how do they vary in different patient populations? Different patient populations include racial/ethnic groups and age by decade (or age groups comparable to those in the Centers for Disease Control and Prevention [CDC]-Society for Assisted Reproductive Technology [SART] national assisted reproductive technology [ART] success rates reports). Risks include high rates of higher order multiples and ovarian hyperstimulation syndrome. Benefits include reduced time to achieve pregnancy, correction of ovulatory dysfunction, possible decreased miscarriage rates, and decreased gestational diabetes risk with Glucophage®.

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